(R)-2-氧代哌啶-3-氨基甲酸叔丁酯合成路线 (共 5 条)
反应条件
1: 100 percent / H2, AcOH / Pd/C / methanol; H2O / 1810.02 - 2585.7 Torr 2: EDC, HOBt, NMM / acetonitrile / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 23 p. 4531 - 4536
反应条件
4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in acetonitrile Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 23 p. 4531 - 4536
反应条件
1: (TMS)2NH / acetonitrile / 48 h / Heating 2: CHCl3 / 4 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 18 p. 5793 - 5808
反应条件
in chloroform Yield given;
参考文献
Tetrahedron Letters, , vol. 40, # 5 p. 935 - 938
反应条件
1: LiHMDS / tetrahydrofuran / Ambient temperature
2: 100 percent / H2 / Pd/C / ethanol / 1551.4 Torr
View Scheme
参考文献
Semple; Rowley; Brunck; Ha-Uong; Minami; Owens; Tamura; Goldman; Siev; Ardecky; Carpenter; Ge; Richard; Nolan; Hakanson; Tulinsky; Nutt; Ripka
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4531 - 4536