2,2-二甲基-1,3-二氧戊环-4-甲胺合成路线 （共 12 条）
反应条件
sodium sulfide in methanol T=55°C; 24 h;
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
反应条件
1: 1-amino-2,3-propanediol With hydrogenchloride in water T=20°C; pH=1; 0.25 h; 2: 2,2-dimethoxy-propane With toluene-4-sulfonic acid in water T=85°C; 0.5 h; 3: With sodium hydroxide in water pH=9;
参考文献
WO2013/66729 A1, ;
Page/Page column 169; 170 ;
WO 2013/066729 A1
反应条件
hydrazine hydrate in methanol Heating;
参考文献
Goubert, Marlene; Toupet, Loic; Sinibaldi, Marie-Eve; Canet, Isabelle
Tetrahedron, 2007 , vol. 63, # 34 p. 8255 - 8266
反应条件
1: LiAlH4 / tetrahydrofuran / 2 h / Heating 2: aq. NaIO4 / tetrahydrofuran / 2 h / 0 °C 3: NH2OH*HCl, Et3N / tetrahydrofuran; methanol / 5 h / 10 °C 4: LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 5 p. 1181 - 1190
反应条件
1: NH2OH*HCl, Et3N / tetrahydrofuran; methanol / 5 h / 10 °C 2: LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 5 p. 1181 - 1190
反应条件
1: 80.3 percent / pyridine / Ambient temperature 2: NaN3 / dimethylsulfoxide / 1.17 h / 100 °C 3: H2 / 5percent Pd/C / methanol / 8 h View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 5 p. 1181 - 1190
反应条件
1: NaN3 / dimethylsulfoxide / 1.17 h / 100 °C 2: H2 / 5percent Pd/C / methanol / 8 h View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 5 p. 1181 - 1190
反应条件
1: 88 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 20 h / 20 °C 2: 90 percent / hydrazine monohydrate / methanol / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 34 p. 8255 - 8266
反应条件
1: 93 percent / aq. NaN3 / dimethylformamide / 6 h / 110 °C 2: 93 percent / aq. Na2S / methanol / 24 h / 55 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7503 - 7507
反应条件
sulfuric acid 3 h; Heating;
参考文献
Danielmeier, Karsten; Steckhan, Eberhard
Tetrahedron: Asymmetry, 1995 , vol. 6, # 5 p. 1181 - 1190
