6,8-二氢-7H-吡咯并[2,3-g]苯并噻唑-7-酮合成路线 （共 3 条）
反应条件
acetic acid; zinc in tetrahydrofuran T=60°C; 2.5 h; Heating / reflux;
参考文献
Glaxo Wellcome Inc.
Patent: US6350747 B1, 2002 ;
Location in patent: Page column 47 ;
反应条件
hydrogenchloride; nitrogen; triethylamine in tetrahydrofuran; methanol; dichloromethane
参考文献
SmithKline Beecham Corporation
Patent: US6369086 B1, 2002 ;
US 6369086 B1
反应条件
1: 49 percent / Zn; acetic acid / tetrahydrofuran / 3.5 h / 60 - 65 °C View Scheme
参考文献
Bramson; Holmes; Hunter; Lackey; Lovejoy; Luzzio; Montana; Rocque; Rusnak; Shewchuk; Veal; Corona; Walker; Kuyper; Davis; Dickerson; Edelstein; Frye; Gampe Jr.; Harris; Hassell
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4339 - 4358
