4-(4-氨基丁基)苯酚合成路线 （共 16 条）
反应条件
boron tribromide in dichloromethane
T=-78 - 20°C;
参考文献
Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger
Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106
反应条件
1: H2 / 10percent Pd/C / dioxane; ethanol / 3 h / 760 Torr / Ambient temperature
2: MeNH2 / methanol / 14 h / Ambient temperature
3: 51 percent / concd. HBr / 1 h / Heating
View Scheme
参考文献
Yasunaga, Tomoyuki; Kimura, Takenori; Naito, Ryo; Kontani, Toru; Wanibuchi, Fumikazu; Yamashita, Hiroshi; Nomura, Tamako; Tsukamoto, Shin-Ichi; Yamaguchi, Tokio; Mase, Toshiyasu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2765 - 2778
反应条件
1: NaOMe, MeOH / dioxane / 12 h / Ambient temperature
2: H2 / 10percent Pd/C / dioxane; ethanol / 3 h / 760 Torr / Ambient temperature
3: MeNH2 / methanol / 14 h / Ambient temperature
4: 51 percent / concd. HBr / 1 h / Heating
View Scheme
参考文献
Yasunaga, Tomoyuki; Kimura, Takenori; Naito, Ryo; Kontani, Toru; Wanibuchi, Fumikazu; Yamashita, Hiroshi; Nomura, Tamako; Tsukamoto, Shin-Ichi; Yamaguchi, Tokio; Mase, Toshiyasu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2765 - 2778
反应条件
dimethylsulfide borane complex in tetrahydrofuran
6 h; Heating;
参考文献
Boden, Phil; Eden, Jon M.; Hodgson, Julie; Horwell, David C.; Hughes, John; McKnight, Alexander T.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Raphy, Jenny; Meecham, Ken; Ratcliffe, Giles S.; Suman-Chauhan, Nirmala; Woodruff, Geoffrey N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1664 - 1675
反应条件
1: 99 percent / KI / dimethylformamide / 12 h / Heating
2: 65 percent / BBr3 / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger
Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106
反应条件
1: 100 percent / SOCl2 / tetrahydrofuran / 2 h / 50 °C
2: 99 percent / KI / dimethylformamide / 12 h / Heating
3: 65 percent / BBr3 / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger
Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106
反应条件
hydrogen bromide
1 h; Heating;
参考文献
Yasunaga, Tomoyuki; Kimura, Takenori; Naito, Ryo; Kontani, Toru; Wanibuchi, Fumikazu; Yamashita, Hiroshi; Nomura, Tamako; Tsukamoto, Shin-Ichi; Yamaguchi, Tokio; Mase, Toshiyasu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2765 - 2778
反应条件
1: DCCI / ethyl acetate / 4 h
2: NH3 (gas) / CH2Cl2 / 12 h
3: 23 percent / 2 M borane*methyl sulfide complex / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Boden, Phil; Eden, Jon M.; Hodgson, Julie; Horwell, David C.; Hughes, John; McKnight, Alexander T.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Raphy, Jenny; Meecham, Ken; Ratcliffe, Giles S.; Suman-Chauhan, Nirmala; Woodruff, Geoffrey N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1664 - 1675
反应条件
1: 91 percent / 48percent HBr, glacial AcOH / 6 h / Heating
2: DCCI / ethyl acetate / 4 h
3: NH3 (gas) / CH2Cl2 / 12 h
4: 23 percent / 2 M borane*methyl sulfide complex / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Boden, Phil; Eden, Jon M.; Hodgson, Julie; Horwell, David C.; Hughes, John; McKnight, Alexander T.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Raphy, Jenny; Meecham, Ken; Ratcliffe, Giles S.; Suman-Chauhan, Nirmala; Woodruff, Geoffrey N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1664 - 1675
反应条件
1: 71 percent / hydrazine monohydrate, KOH / bis-(2-hydroxy-ethyl) ether / a) reflux, 3 h, b) 180 deg C, 4 h
2: 91 percent / 48percent HBr, glacial AcOH / 6 h / Heating
3: DCCI / ethyl acetate / 4 h
4: NH3 (gas) / CH2Cl2 / 12 h
5: 23 percent / 2 M borane*methyl sulfide complex / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Boden, Phil; Eden, Jon M.; Hodgson, Julie; Horwell, David C.; Hughes, John; McKnight, Alexander T.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Raphy, Jenny; Meecham, Ken; Ratcliffe, Giles S.; Suman-Chauhan, Nirmala; Woodruff, Geoffrey N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1664 - 1675
