4-甲氧基-3-硝基苄硫基乙酸合成路线 （共 9 条）
反应条件
sodium hydroxide in methanol T=20°C; 3 h; Inert atmosphere;
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
1: mercaptoacetic acid With sodium hydroxide in methanol 0.5 h; 2: 4-methoxy-3-nitrobenzyl chloride in methanol T=20°C; 4 h; Heating / reflux;
参考文献
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
Patent: WO2006/104668 A2, 2006 ;
Location in patent: Page/Page column 32-33 ;
反应条件
1: in methanol 4 h; Heating / reflux; 2: With hydrogenchloride; water in methanol T=0°C;
参考文献
ONCONOVA THERAPEUTICS, INC.
Patent: WO2008/33475 A2, 2008 ;
Location in patent: Page/Page column 53 ;
参考文献
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Patent: US2010/305059 A1, 2010 ;
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 18 h / Inert atmosphere; Reflux 2: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
1: phosphorus tribromide / toluene / 0.5 h / 40 - 100 °C / Inert atmosphere 2: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
1: sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C / Inert atmosphere 2: phosphorus tribromide / toluene / 0.5 h / 40 - 100 °C / Inert atmosphere 3: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
dihydrogen peroxide in acetic acid T=50°C; 6 h; chemoselective reaction;
参考文献
Chahrour, Osama; Abdalla, Ashraf; Lam, Frankie; Midgley, Carol; Wang, Shudong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3066 - 3069
反应条件
1: dihydrogen peroxide / acetic acid / 6 h / 50 °C
2: piperidine / pyridine / 36 h / 20 °C
4: sodium acetate
5: water; sodium carbonate
View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
