5-(4-氯苯基)-3,4-二氢-2H-吡咯合成路线 （共 9 条）
反应条件
triphenylphosphine in pentane 14 h; Ambient temperature;
参考文献
De Kimpe, Norbert; Tehrani, Kourosch Abbaspour; Stevens, Christian; De Cooman, Paul
Tetrahedron, 1997 , vol. 53, # 10 p. 3693 - 3706
反应条件
1: pyrrolidin-2-one With chloro-trimethyl-silane; triethylamine in diethyl ether 0.5 h; Heating; 2: 4-chlorophenyl-magnesium bromide in diethyl ether 3 h; Heating;
参考文献
Coindet, Cecile; Comel, Alain; Kirsch, Gilbert
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6101 - 6104
反应条件
in tetrahydrofuran 3 h; RefluxInert atmosphere;
参考文献
Chen, Fei; Ding, Ziyuan; Qin, Jie; Wang, Tianli; He, Yanmei; Fan, Qing-Hua
Organic Letters, 2011 , vol. 13, # 16 p. 4348 - 4351
反应条件
1: NaN3; NaI / dimethylsulfoxide / 15 h / 55 °C 2: triphenylphosphine / hexane / 14 h / 20 °C View Scheme
参考文献
De Kimpe, Norbert; Tehrani, Kourosch Abbaspour; Stevens, Christian; De Cooman, Paul
Tetrahedron, 1997 , vol. 53, # 10 p. 3693 - 3706
反应条件
iodine; magnesium 1.) ether, 0.5 h, 2.) ether, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Elslager, Edward F.; Johnson, Judith L.; Werbel, Leslie M.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 140 - 145
反应条件
methanol; nickel Hydrogenation;
参考文献
Knott
Journal of the Chemical Society, 1948 , p. 186
反应条件
iodine; magnesium 1.) Et2O, reflux, 1 h, 2.) THF, room temperature, 15 h; Yield given. Multistep reaction;
参考文献
Keppens, Marian; De Kimpe, Norbert; Fonck, Gwendolien
Synthetic Communications, 1996 , vol. 26, # 16 p. 3097 - 3102
参考文献
Mariano, Patrick S.; Leone-Bay, Andrea
Tetrahedron Letters, 1980 , vol. 21, # 48 p. 4581 - 4584
反应条件
hydrogen; platinum on activated charcoal in toluene T=28°C; P=2611.6 Torr; 44.9 h; Yield given;
参考文献
Rogers, Claude J.; Dickerson, Tobin J.; Brogan, Andrew P.; Janda, Kim D.
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3705 - 3708
