5-(4-溴苯基)-3,4-二氢-2H-吡咯合成路线 (共 9 条)
反应条件
triethyl phosphite in dimethyl sulfoxide 0.166667 h; microwave irradiation;
参考文献
Singh, Pradeep N.D.; Klima, Rodney F.; Muthukrishnan, Sivaramakrishnan; Murthy, Rajesh S.; Sankaranarayanan, Jagadis; Stahlecker, Heidi M.; Patel, Bhavika; Gudmundsdottir, Anna D.
Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4213 - 4217
反应条件
1: With trifluoroacetic acid 6 h; 2: With sodium hydroxide in water pH=13 - 14;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 196 ;
反应条件
sodium azide; triethyl phosphite in dimethyl sulfoxide intramolecular aza-Wittig reaction; 0.466667 h; microwave irradiation;
参考文献
Singh, Pradeep N.D.; Klima, Rodney F.; Muthukrishnan, Sivaramakrishnan; Murthy, Rajesh S.; Sankaranarayanan, Jagadis; Stahlecker, Heidi M.; Patel, Bhavika; Gudmundsdottir, Anna D.
Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4213 - 4217
反应条件
in pentane T=20°C; 18 h;
参考文献
Vaultier, M.; Lambert, P. H.; Carrie, R.
Bulletin de la Societe Chimique de France, 1986 , # 1 p. 83 - 92
反应条件
1: pyrrolidin-2-one With chloro-trimethyl-silane; triethylamine in diethyl ether 0.5 h; Heating; 2: 4-bromophenyllithium in diethyl ether 3 h; Heating;
参考文献
Coindet, Cecile; Comel, Alain; Kirsch, Gilbert
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6101 - 6104
反应条件
in tetrahydrofuran 3 h; Inert atmosphereReflux;
参考文献
Chang, Mingxin; Li, Wei; Hou, Guohua; Zhang, Xumu
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3121 - 3125
反应条件
1: With sodium hydride 2: With hydrogenchloride in water Reflux;
参考文献
Shevchenko, Nikolay E.; Vlasov, Katja; Nenajdenko, Valentine G.; Roeschenthaler, Gerd-Volker
Tetrahedron, 2011 , vol. 67, # 1 p. 69 - 74
参考文献
Mariano, Patrick S.; Leone-Bay, Andrea
Tetrahedron Letters, 1980 , vol. 21, # 48 p. 4581 - 4584
反应条件
sodium tetrahydroborate; water in methanol T=-41 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 196 ;