2-氨基-3-甲基苯甲酸甲酯合成路线 （共 19 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=20°C; 10 h;
参考文献
Tetrahedron, , vol. 69, # 32 p. 6679 - 6686
反应条件
1: With caesium carbonate in DMF (N,N-dimethyl-formamide) 0.5 h; 2: With methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
WO2004/29050 A1, ;
Page 64 ;
WO 2004/029050 A1
反应条件
1: 2-amino-3-methyl benzoic acid With caesium carbonate in N,N-dimethyl-formamide T=20°C; 0.666667 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C;
参考文献
WO2008/65508 A1, ;
Page/Page column 27-28 ;
反应条件
sulfuric acid 72 h; Reflux;
参考文献
Tetrahedron, , vol. 65, # 2 p. 563 - 578
反应条件
4-(N,N-dimethlyamino)pyridine in methanol T=60°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3753 - 3757
反应条件
in 1,4-dioxane; N-methyl-acetamide; methanol
反应条件
1: zinc dust; alkaline alcohol 2: hydrogen chloride View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. <4> 1, p. 216
Bulletin de la Societe Chimique de France, , vol. <4> 9, p. 602,657
反应条件
1: fuming nitric acid 2: HCl 3: methanol; tin; hydrochloric acid View Scheme
参考文献
Chemische Berichte, , vol. 40, p. 4413
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 22 p. 3386 - 3396
反应条件
dihydrogen peroxide; sodium methylate 1.) 0-10 deg C 2.) room temperature, 30 min; Yield given. Multistep reaction;
参考文献
Angewandte Chemie, , vol. 93, # 10 p. 914 - 915
