2-氨基-3-甲基苯甲酸甲酯合成路线 （共 19 条）
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 6 h / 20 °C 2.1: potassium acetate / chloroform / 0.25 h / 0 - 20 °C 2.2: 18 h / 65 °C 3.1: hydrogenchloride / water; methanol / 2 h / 20 °C View Scheme
参考文献
Kim, Mi Kyoung; Shin, Heerim; Cho, Seo Young; Chong, Youhoon
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 1156 - 1162
反应条件
1: With acetic anhydride; isopentyl nitrite in chloroform T=-40 - 20°C; 1 h; 2: With potassium acetate 24 h; Heating / reflux;
参考文献
Memory Pharmaceuticals Corporation
Patent: WO2004/29050 A1, 2004 ;
Location in patent: Page 64 ;
WO 2004/029050 A1
反应条件
1: With 2-methylpropane-2-thiol; sodium nitrite in ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide T=0 - 20°C; 2: With potassium tert-butylate in dimethyl sulfoxide T=20°C; 2 h; 3: With hydrogenchloride in dimethyl sulfoxide
参考文献
Barber, Christopher Gordon; Bunnage, Mark Edward; Harvey, John Wilson; Mathias, John Paul
Patent: US2005/20611 A1, 2005 ;
Location in patent: Page/Page column 44 ;
反应条件
hydrogenchloride; copper(I) bromide; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
bromine in acetic acid T=20°C; 0.5 h;
参考文献
Helvetica Chimica Acta, , vol. 87, # 6 p. 1333 - 1356
反应条件
1: With acetic anhydride in chloroform
T=20 - 40°C; 1 h;
2: With potassium acetate; isopentyl nitrite in chloroform
T=20°C; 24 h; Heating / reflux;
3: With hydrogenchloride in methanol; water
T=20°C; 18 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/92890 A2, 2005 ;
Location in patent: Page/Page column 77-79 ;
WO 2005/092890 A2
反应条件
1: With sulfuryl dichloride in acetonitrile
T=50 - 55°C; 3.25 h;
2: With sodium hydroxide in water; acetonitrile
T=5°C; pH=6; 0.166667 h; Product distribution / selectivity;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/62978 A1, 2006 ;
Location in patent: Page/Page column 23 ;
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water
T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
hydrogenchloride; tetrafluoroboric acid; sodium nitrite in water
T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
