lithium aluminium tetrahydride in diethyl ether 16 h; Heating;

1: 1) SOCl2, 2) pyridine / 1) DMF, 1 h, r.t.; 2 h, reflux, 2) CH2Cl2, 0 deg C, 16 h 2: 2) NaOH / 1) PH-CH2COOEt, 2 h, 150 deg C, 2) aq. MeOH, 16 h, r.t. 3: H2NOH*HCl / ethanol; pyridine / 3 h / Heating 4: LiAlH4 / diethyl ether / 16 h / Heating View Scheme