6-羟基-3,4-二氢异喹啉-1(2H)-酮合成路线 （共 7 条）
反应条件
boron tribromide in dichloromethane T=-78 - 20°C; 5 h;
参考文献
Fu, Liqiang; Liu, Xin; Ling, Chenyu; Cheng, Jianjun; Guo, Xingsheng; He, Huili; Ding, Shi; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 814 - 819
反应条件
sodium azide; trifluoroacetic acid 2 h; Heating / reflux;
参考文献
PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2007/1249 A1, 2007 ;
Location in patent: Page/Page column 52-53 ;
反应条件
1: polyphosphoric acid / 3 h / 140 °C 2: boron tribromide / dichloromethane / 5 h / -78 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 814 - 819
反应条件
1: triethylamine / dichloromethane / 3 h / 0 °C 2: polyphosphoric acid / 3 h / 140 °C 3: boron tribromide / dichloromethane / 5 h / -78 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 814 - 819
反应条件
1: sodium azide / methanesulfonic acid; dichloromethane / 0 - 20 °C 2: boron tribromide / dichloromethane / -78 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2452 - 2468
反应条件
potassium carbonate in acetone 16 h; Heating;
参考文献
Fisher, Matthew J.; Gunn, Bruce; Harms, Cathy S.; Kline, Allen D.; Mullaney, Jeffrey T.; Nunes, Anne; Scarborough, Robert M.; Arfsten, Ann E.; Skelton, Marshall A.; Um, Suzane L.; Utterback, Barbara G.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2085 - 2101
反应条件
triethylamine in dichloromethane
2 h;
参考文献
DECIPHERA PHARMACEUTICALS, LLC
Patent: WO2006/71940 A2, 2006 ;
Location in patent: Page/Page column 420 ;
WO 2006/071940 A2
