6-甲氧基-3,4-二氢-1(2H)-异喹啉合成路线 （共 26 条）
反应条件
1: 95 percent / H2, NH3 / Raney-Ni / ethanol / 4 h / 120 °C / 45600 Torr 2: Et3N / CH2Cl2 / 1 h 3: polyphosphoric acid / 1 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 324, # 8 p. 509 - 518
反应条件
1: trifluoromethylsulfonic anhydride; alpha-chloropyridine / dichloromethane / 0.33 h / -78 °C / |Inert atmosphere 2: boron trifluoride diethyl etherate / dichloromethane / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 5 p. 965 - 971
反应条件
phosphoric acid in dichloromethane 2 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 3 p. 1003 - 1005
反应条件
1: benzene / Heating 2: 268 mg / H3PO4 / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 3 p. 1003 - 1005
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 86 percent / LAH / tetrahydrofuran / 5 h / 80 °C 2: 84 percent / 10percent Pd/C / 1,3,5-trimethyl-benzene / 0.5 h / 190 - 200 °C View Scheme
参考文献
Shanker, P. Sathya; Rao, G. S. R. Subba
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 12 p. 1209 - 1213
反应条件
1: 2-(3-methoxy-phenyl)-ethylamine 2: triethylamine / dichloromethane; ethyl acetate; tetrahydrofuran 3: triethylamine; Tf2O / dichloromethane View Scheme
反应条件
in 2-(3-methoxy-phenyl)-ethylamine
参考文献
Smithkline Beecham Corporation
Patent: US2011/124559 A1, 2011 ;
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 90 percent / 48percent aq. HBr / 3 h / 120 °C View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1: 2-(3-methoxy-phenyl)-ethylamine 2: triethylamine / dichloromethane; ethyl acetate; tetrahydrofuran 3: triethylamine; Tf2O / dichloromethane View Scheme
参考文献
Smithkline Beecham Corporation
Patent: US2011/124559 A1, 2011 ;
