3,4-二氢-7-羟基-2(1H)-喹啉酮合成路线 （共 27 条）
反应条件
AlCl3, aluminium chloride in N,N-dimethyl acetamide T=140 - 150°C; Friedel Crafts Alkylation; 2.75 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/94009 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With AlCl3, aluminium chloride T=210°C; 0.5 h; 2: With water T=20°C;
参考文献
WYETH
Patent: WO2008/150848 A1, 2008 ;
Location in patent: Page/Page column 132-133 ;
WO 2008/150848 A1
反应条件
1: With AlCl3, aluminium chloride T=155 - 165°C; 4 h; 2: With methanol; sodium hydroxide in water T=20°C; pH=7; 1 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Davidi, Guy; Klopfer, Eyal; Arad, Oded; Kaspi, Joseph
Patent: US2006/79690 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
ammonium formate on silica gel; zinc in carbon dioxide T=50°C; P=90009 Torr; Autoclaveliquid CO2;
参考文献
Dinesh, Bhima Reddy; Baba, A. Ramesha; Sankar, K. Udaya; Gowda, D. Channe
Journal of Chemical Research, 2008 , # 5 p. 287 - 288
参考文献
O'Neill, Brian Thomas; Nagel, Arthur Adam; Humphrey, John Michael; Sobolov-Jaynes, Susan Beth; Chappie, Thomas Allen; Vincent, Lawrence Albert; Arnold, Eric Platt; Huang, Jianhua
Patent: US2003/87925 A1, 2003 ;
US 20030087925 A1
反应条件
1: With palladium diacetate in 1,4-dioxane T=25°C; Heck reduction-cyclisation-debenzylation reaction; 6 h; 2: With hydrogen; palladium diacetate; carbon in 1,4-dioxane T=50°C; Heck reduction-cyclisation-debenzylation reaction; 24 h;
参考文献
Felpin, Francois-Xavier; Coste, Jerome; Zakri, Cecile; Fouquet, Eric
Chemistry - A European Journal, 2009 , vol. 15, # 29 p. 7238 - 7245
反应条件
1: 96 percent / NaHCO3 / CH2Cl2 / 4 h / 20 °C 2: 61.5 percent / N,N-dimethylacetamide; aluminium trichloride / 2 h / 150 - 160 °C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 56, # 10 p. 673 - 677
参考文献
US4435397 A1, ;
US 4435397 A
反应条件
1.1: BF3/MeOH / methanol / 5 h / |Inert atmosphere; |Reflux 1.2: 0.33 h / -15 - 0 °C 2.1: sodium acetate; palladium diacetate / methanol / 12 h / 20 °C 3.1: carbon; hydrogen / methanol / 24 h / 750.08 Torr View Scheme
反应条件
1: sodium hydrogencarbonate / acetonitrile / 0 °C 2: AlCl3, aluminium chloride / dichloromethane View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
