2,3,4-三甲氧基-6-羟基苯乙酮合成路线 （共 42 条）
反应条件
1.1: pyridine / 15 h / 20 °C / Inert atmosphere
2.1: pyridine; potassium hydroxide / 3 h / 70 °C
2.2: Cooling with ice
3.1: sulfuric acid; acetic acid / 1.5 h / 80 °C
4.1: boron tribromide / dichloromethane / 1.5 h / 0 °C / Inert atmosphere
4.2: 0.5 h / 20 °C / Inert atmosphere
5.1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran; methanol / 1.5 h / 20 °C
View Scheme
参考文献
Soulage, Christophe O.; Grand, Lucie; Geloen, Alain; Chambert, Stephane
Tetrahedron Letters, 2012 , vol. 53, # 5 p. 480 - 483
反应条件
1: KOH / ethanol; H2O / 72 h / Ambient temperature
2: pyridine / 8 h / Heating
View Scheme
参考文献
Nath, Swadhin; Bhattacharyya, Anjan; Sengupta, P. K.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 709 - 710
反应条件
1: CF3COOH / benzene
2: KOH / pyridine
3: H2SO4 / acetic acid
4: H2 / Pd-C / ethyl acetate
5: AlCl3 / CH2Cl2
View Scheme
参考文献
Bhardwaj, D. K.; Chand, Gyan; Jain, R. K.; Munjal, Anita
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 9 p. 932 - 933
反应条件
1: 1.2 g
2: 0.28 g / DDQ
3: 0.12 g / BCl3 / -70 °C
View Scheme
参考文献
Iinuma; Iwashima; Matsuura
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4935 - 4941
反应条件
potassium hydroxide in ethanol; water
72 h; Ambient temperature;
参考文献
Nath, Swadhin; Bhattacharyya, Anjan; Sengupta, P. K.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 709 - 710
反应条件
1: potassium hydroxyde
2: 0.8 g / 35percent H2O2, 10percent potassium hydroxide / methanol / 0.25 h / Ambient temperature
3: 200 mg / KOH
4: boron trichloride / CH2Cl2 / -60 °C
View Scheme
参考文献
Iinuma, Munekazu; Roberts, Margaret F.; Matlin, Stephen A.; Stacey, Vivien E.; Timmermann, Barbara N.; et al.
Phytochemistry (Elsevier), 1985 , vol. 24, # 6 p. 1367 - 1368
反应条件
1: 89 percent / KOH / ethanol / 0 - 20 °C
2: 74 percent / iodine / dimethylsulfoxide / 2 h / 190 - 200 °C
3: 58 percent / BBr3 / CH2Cl2 / 13 h / -80 - 20 °C
View Scheme
参考文献
Gao, Hong; Nishida, Jun; Saito, Shizuka; Kawabata, Jun
Molecules, 2007 , vol. 12, # 1 p. 86 - 97
反应条件
1: 91 percent / NaH
2: 27 percent / pyridine / CHCl3 / 60 °C
View Scheme
参考文献
Combes; Finet; Siri
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 38 - 44
反应条件
1: KOH / ethanol
2: 91 percent / HBr; glacial AcOH / 2 h / Heating
View Scheme
参考文献
Huang, Wen-Hsin; Chien, Pei-Yu; Yang, Ching-Huey; Lee, An-Rong
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 339 - 340
反应条件
1: pyridine / 3 h / 120 °C
2: KOH, pyridine / 4 h / 60 °C
3: 88 percent / AcONa, AcOH / 3 h / 140 - 145 °C
4: 97 percent / H2 / 10percent Pd/C / methanol; ethyl acetate
View Scheme
参考文献
Horie, Tokunaru; Tsukayama, Masao; Kourai, Hiroki; Yokoyama, Chieko; Furukawa, Masayuki; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2256 - 2262
