ammonia in methanol; water T=80°C; 0.5 h;

1: 91 percent / NH3 (15percent) / methanol / 0 °C 2: 73 percent / H2 / Pd-C (10percent) / acetic acid 3: Et(i-Pr)2N / CH2Cl2 / Ambient temperature 4: K2CO3 / acetone / Heating 5: 6 percent / NH3 / methanol; H2O / 0.5 h / 80 °C View Scheme

1: 73 percent / H2 / Pd-C (10percent) / acetic acid 2: Et(i-Pr)2N / CH2Cl2 / Ambient temperature 3: K2CO3 / acetone / Heating 4: 6 percent / NH3 / methanol; H2O / 0.5 h / 80 °C View Scheme

sodium hydroxide in water 20 h; Heating;