7-氨基-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸合成路线 （共 40 条）
反应条件
sodium hydrogencarbonate in acetone 4 h;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Aleksanyan, M. V.; Ter-Zakharyan, Yu. Z.; Oganyan, Sh. G.; Engoyan, A. P.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 115 - 119
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 186 - 191
反应条件
sodium hydrogencarbonate in acetone 4 h;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Aleksanyan, M. V.; Ter-Zakharyan, Yu. Z.; Oganyan, Sh. G.; Engoyan, A. P.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 115 - 119
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 186 - 191
反应条件
ammonia; immobolized Escherichia coli wild type penicillin G acylase with mutations B:F24A and B:V148L in water T=20°C; pH=7.2; Enzymatic reaction;
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; KOSTER, Adrianus Jan; DOES, VAN DER, Thomas
Patent: WO2012/32040 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With TMG in dichloromethane T=-50 - -30°C; 5 h; 2: With hydrogenchloride in dichloromethane; water T=0°C; pH=0 - 1; 10 h; Further stages.;
参考文献
Kemperman, Gerardus J.; Zhu, Jie; Klunder, Antonius J. H.; Zwanenburg, Binne
European Journal of Organic Chemistry, 2001 , # 10 p. 1817 - 1820
反应条件
α-amino ester hydrolase from Xanthomonas citri T=25°C; pH=6.2; aq. phosphate bufferEnzymatic reaction;
参考文献
Blum, Janna K.; Bommarius, Andreas S.
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 67, # 1-2 p. 21 - 28
反应条件
penicillin acylasefrom Escherichia coli; water
参考文献
Brugging, Alle; Roos, Eric C.; De Vroom, Erik
Organic Process Research and Development, 1998 , vol. 2, # 2 p. 128 - 133
反应条件
potassium phosphate buffer T=30°C; enzyme assay; α-amino acid ester hydrolase from Xanthomonas citri, Michaelis const., substrate specificity;
参考文献
Brugging, Alle; Roos, Eric C.; De Vroom, Erik
Organic Process Research and Development, 1998 , vol. 2, # 2 p. 128 - 133
反应条件
potassium phosphate buffer T=30°C; α-amino acid ester hydrolase from Xanthomonas citri; kinetics of the acyl transfer;
参考文献
Kato, Koichi
Agricultural and Biological Chemistry, 1980 , vol. 44, # 5 p. 1083 - 1088
反应条件
sodium hydrogencarbonate in acetone 4 h;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Aleksanyan, M. V.; Ter-Zakharyan, Yu. Z.; Oganyan, Sh. G.; Engoyan, A. P.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 115 - 119
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 186 - 191
反应条件
1: With triethylamine in dichloromethane; water T=-40 - 0°C; 3 h; 2: With hydrogenchloride in dichloromethane; water 1 h; 3: With sodium hydroxide in dichloromethane; water T=0°C; pH=3.2; 2 h;
参考文献
CJ CORPORATION
Patent: WO2005/42543 A1, 2005 ;
Location in patent: Page/Page column 20 ;
