7-氨基-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸合成路线 （共 40 条）
反应条件
1: 7-Aminodesacetoxycephalosporanic acid With 1H-imidazole; chloro-trimethyl-silane in dichloromethane 3 - 4 h; Heating / reflux; 2: C16H19NO7 in DMF (N,N-dimethyl-formamide); dichloromethane T=-45 - -20°C; 2.5 h; 3: With hydrogenchloride in DMF (N,N-dimethyl-formamide); dichloromethane; water T=0 - 5°C; 0.25 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2004/83172 A2, 2004 ;
Location in patent: Page 8 ;
反应条件
formic acid; ammonia; immobilized Pen-G acylase mutant Phe-24-Ala in water T=12°C; pH=7.3; 2.5 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
Brugging, Alle; Roos, Eric C.; De Vroom, Erik
Organic Process Research and Development, 1998 , vol. 2, # 2 p. 128 - 133
反应条件
ammonia; immobolized Escherichia coli wild type penicillin G acylase with mutations B:F24A and B:V148L in water T=20°C; pH=7.2; Enzymatic reaction;
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; KOSTER, Adrianus Jan; DOES, VAN DER, Thomas
Patent: WO2012/32040 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With TMG in dichloromethane T=-50 - -30°C; 5 h; 2: With hydrogenchloride in dichloromethane; water T=0°C; pH=0 - 1; 10 h; Further stages.;
参考文献
Kemperman, Gerardus J.; Zhu, Jie; Klunder, Antonius J. H.; Zwanenburg, Binne
European Journal of Organic Chemistry, 2001 , # 10 p. 1817 - 1820
反应条件
α-amino ester hydrolase from Xanthomonas citri T=25°C; pH=6.2; aq. phosphate bufferEnzymatic reaction;
参考文献
Blum, Janna K.; Bommarius, Andreas S.
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 67, # 1-2 p. 21 - 28
反应条件
penicillin acylasefrom Escherichia coli; water
参考文献
Brugging, Alle; Roos, Eric C.; De Vroom, Erik
Organic Process Research and Development, 1998 , vol. 2, # 2 p. 128 - 133
反应条件
potassium phosphate buffer T=30°C; enzyme assay; α-amino acid ester hydrolase from Xanthomonas citri, Michaelis const., substrate specificity;
参考文献
Brugging, Alle; Roos, Eric C.; De Vroom, Erik
Organic Process Research and Development, 1998 , vol. 2, # 2 p. 128 - 133
反应条件
potassium phosphate buffer T=30°C; α-amino acid ester hydrolase from Xanthomonas citri; kinetics of the acyl transfer;
参考文献
Kato, Koichi
Agricultural and Biological Chemistry, 1980 , vol. 44, # 5 p. 1083 - 1088
反应条件
sodium hydrogencarbonate in water; acetone T=0 - 20°C; 6 h;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
反应条件
chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine 1.) acetone, from 0 deg C, 30 min, to RT, 2 h, 2.) acetone, water, 4 h; Yield given. Multistep reaction;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
