(S)-2-乙氧基-3-(4-羟基苯基)丙酸乙酯合成路线 （共 15 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=2844.39 Torr; 10 h;
参考文献
WO2008/10238 A2, ;
Page/Page column 85-86 ;
反应条件
thionyl chloride 3 h; Heating / reflux;
参考文献
WO2008/108602 A1, ;
Page/Page column 45; 27 ;
反应条件
palladium monocarbide in ethyl acetate
反应条件
1: H2SO4 2: imidazole / dimethylformamide / 18 h / 25 °C 3: CH3COH; Et3SiH; BiBr3 / acetonitrile / 25 °C 4: H2 / Pd/C / ethanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 12 p. 4695 - 4705
反应条件
1: (+)-DIP-Cl; Et3N / tetrahydrofuran 2: K2CO3 / ethanol / 24 h / Heating 3: 60.81 g / NaOH / H2O / 2 h / 20 °C 4: H2SO4 5: imidazole / dimethylformamide / 18 h / 25 °C 6: CH3COH; Et3SiH; BiBr3 / acetonitrile / 25 °C 7: H2 / Pd/C / ethanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 12 p. 4695 - 4705
反应条件
1: imidazole / dimethylformamide / 18 h / 25 °C 2: CH3COH; Et3SiH; BiBr3 / acetonitrile / 25 °C 3: H2 / Pd/C / ethanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 12 p. 4695 - 4705
反应条件
1: CH3COH; Et3SiH; BiBr3 / acetonitrile / 25 °C 2: H2 / Pd/C / ethanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 12 p. 4695 - 4705
反应条件
1: K2CO3 / ethanol / 24 h / Heating 2: 60.81 g / NaOH / H2O / 2 h / 20 °C 3: H2SO4 4: imidazole / dimethylformamide / 18 h / 25 °C 5: CH3COH; Et3SiH; BiBr3 / acetonitrile / 25 °C 6: H2 / Pd/C / ethanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 12 p. 4695 - 4705
反应条件
1.1: (+)-DIP-Cl; Et3N / tetrahydrofuran 1.2: K2CO3 / ethanol 2.1: 60.81 g / NaOH / H2O / 2 h / 20 °C 3.1: H2SO4 4.1: imidazole / dimethylformamide / 18 h / 25 °C 5.1: CH3COH; Et3SiH; BiBr3 / acetonitrile / 25 °C 6.1: H2 / Pd/C / ethanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 12 p. 4695 - 4705
反应条件
1: hydrogen; 5 palladium on charcoal / isopropanol acetate / 3 h / 22 - 25 °C / 3000.3 Torr / |Autoclave; |Inert atmosphere 2: isopropanol acetate / 0.17 h / 45 - 47 °C 3: hydrogen iodide / water 4: hydrogenchloride; water / ethyl acetate / 5 h / 79 - 80 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 838 - 845
