2,4-二甲基嘧啶-5-甲酸乙酯合成路线 （共 11 条）
反应条件
sodium ethanolate in ethanol 24 h; Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1364949 A1, 2003 ;
Location in patent: Page/Page column 100 ;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1402900 A1, 2004 ;
反应条件
sodium ethanolate in ethanol 24 h; Heating;
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
1: 25 - 28 °C 2: sodium ethanolate / ethanol / 4 h / Reflux View Scheme
反应条件
sodium ethanolate T=20°C;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 41, # 2 p. 262 - 264
参考文献
Helvetica Chimica Acta, , vol. 41, p. 1806,1812
反应条件
1: methanol; NH3 2: methanol; bromine 3: aqueous Ba(OH)2 View Scheme
参考文献
Urban; Schnider
Helvetica Chimica Acta, 1958 , vol. 41, p. 1806,1812
反应条件
sodium hydroxide 1 h; Ambient temperature;
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
hydrazine hydrate in methanol
T=20 - 45°C; 0.5 h;
参考文献
Brown; Cowden
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1469 - 1475
反应条件
1: 83 percent / hydrazine hydrate / methanol / 0.5 h / 20 - 45 °C
2: 96 percent / KOH / ethanol / 1 h / 20 - 25 °C
3: 50 percent / H2SO4 conc. / 0.08 h
View Scheme
参考文献
Brown; Cowden
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1469 - 1475
