3-溴-2-(溴甲基)丙酸甲酯合成路线 （共 9 条）
反应条件
sulfuric acid in 1,2-dichloro-ethane 19 h; Heating;
参考文献
Haynes, Richard K.; Katsifis, Andrew; Vonwiller, Simone C.
Australian Journal of Chemistry, 1984 , vol. 37, # 7 p. 1571 - 1578
参考文献
Synthetic Communications, , vol. 16, # 4 p. 387 - 392
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in tetrachloromethane T=0°C; 1 h;
参考文献
Charlton, J. L.; Sayeed, V. A.; Lypka, G. N.
Synthetic Communications, 1981 , vol. 11, # 11 p. 931 - 934
反应条件
sodium azide in N,N-dimethyl-formamide
参考文献
Lee, Kyeong; Boovanahalli, Shanthaveerappa K.; Nam, Ky-Youb; Kang, Sang-Uk; Lee, Mijeoung; Phan, Jason; Wu, Li; Waugh, David S.; Zhang, Zhong-Yin; Kyoung, Tai No; Jung, Jun Lee; Burke Jr., Terrence R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4037 - 4042
反应条件
sodium azide in N,N-dimethyl-formamide 15 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Nanjappan, Palaniappa; Raju, Natarajan; Ramalingam, Kondareddiar; Nowotnik, David P.
Tetrahedron, 1994 , vol. 50, # 29 p. 8617 - 8632
反应条件
1: NaN3 / dimethylformamide 2: H2; HCl / Pd/C / methanol / 1810.02 Torr View Scheme
参考文献
Lee, Kyeong; Boovanahalli, Shanthaveerappa K.; Nam, Ky-Youb; Kang, Sang-Uk; Lee, Mijeoung; Phan, Jason; Wu, Li; Waugh, David S.; Zhang, Zhong-Yin; Kyoung, Tai No; Jung, Jun Lee; Burke Jr., Terrence R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4037 - 4042
反应条件
1: methanol; dimethylformamide 2: N2O4 / CCl4 3: (i) NaH, THF, (ii) /BRN= 506007/ View Scheme
参考文献
Mueller,L.G.; Lawton,R.G.
Journal of Organic Chemistry, 1979 , vol. 44, p. 4741 - 4742
反应条件
1: With triethylamine in acetonitrile T=100°C; 12 h; 2: With water; acetic acid in acetonitrile 3 h; Heating / reflux;
参考文献
ABBOTT LABORATORIES
Patent: WO2007/118185 A2, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/118185 A2
反应条件
sodium methylate in methanol
T=0°C; 1 h;
参考文献
Haynes, Richard K.; Katsifis, Andrew; Vonwiller, Simone C.
Australian Journal of Chemistry, 1984 , vol. 37, # 7 p. 1571 - 1578
