3-(4-甲氧基苯基)丙酸合成路线 （共 50 条）
反应条件
potassium hydroxide in ethanol 12 h; Heating;
参考文献
Jacobsen, Eric N.; Deng, Li; Furukawa, Yoshiro; Martinez, Luis E.
Tetrahedron, 1994 , vol. 50, # 15 p. 4323 - 4334
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 45 °C 3: sodium dihydrogen phosphate monohydrate; cyclohexene / water; tert-butyl alcohol / 10 h / 0 - 20 °C View Scheme
参考文献
Kawate, Tomohiko; Iwase, Noriaki; Shimizu, Motohisa; Stanley, Sarah A.; Wellington, Samantha; Kazyanskaya, Edward; Hung, Deborah T.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 22 p. 6052 - 6059
反应条件
1: piperidine; pyridine / 4 h / 90 °C 2: thionyl chloride / 4 h / Reflux 3: bromine / dichloromethane / 0.33 h / 0 °C 4: potassium hydroxide / ethanol / 6 h / Reflux View Scheme
参考文献
Zhao, Baoli
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 35 p. 7108 - 7119
反应条件
1: Br2 / CH2Cl2 / 0 °C 2: KOH / ethanol / 4 h / Heating View Scheme
参考文献
Jacobsen, Eric N.; Deng, Li; Furukawa, Yoshiro; Martinez, Luis E.
Tetrahedron, 1994 , vol. 50, # 15 p. 4323 - 4334
反应条件
1: 1.) AlCl3, 3.) NaHCO3 2: 1 N aq. HCl / CH2Cl2 3: 0.24 N aq. NaOH / ethanol / 1.5 h View Scheme
参考文献
Wadsworth, Donald H.; Geer, Susan M.; Detty, Michael R.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3662 - 3668
反应条件
1: bromine 2: alcoholic dimethylamine / 20 °C 3: alcoholic KOH-solution View Scheme
参考文献
Sun, Jie; Ding, Wei Xian; Zhang, Ke Yun; Zou, Yong
Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 667 - 670
反应条件
1: copper(l) iodide; palladium diacetate; caesium carbonate; silver carbonate / DCE / 24 h / 80 °C 2: sodium hydroxide / ethanol; water / 0.5 h / 20 °C View Scheme
参考文献
Qu, Xiaoming; Li, Tingyi; Sun, Peng; Zhu, Yan; Yang, Hailong; Mao, Jincheng
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6938 - 6942
反应条件
1: SOCl2 / 4 h / Heating 2: Br2 / CH2Cl2 / 0 °C 3: KOH / ethanol / 4 h / Heating View Scheme
参考文献
Lee; Tseng
Synthesis, 2001 , # 15 p. 2247 - 2254
反应条件
1: 86 percent / benzene / 2 h / Ambient temperature 2: 67 percent / 1 h / 200 °C / 0.01 Torr 3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C to room temp., 2.) 30 min, room temp. View Scheme
参考文献
Braga, A. L.; Comasseto, J. V.; Petragnani, N.
Synthesis, 1984 , # 3 p. 240 - 243
反应条件
1: bromine / dichloromethane / 0.33 h / 0 °C 2: potassium hydroxide / ethanol / 6 h / Reflux View Scheme
参考文献
Sun, Jie; Ding, Wei Xian; Zhang, Ke Yun; Zou, Yong
Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 667 - 670
