4-氨基吡咯并[3,2-D]嘧啶合成路线 （共 4 条）
反应条件
ammonium hydroxide in 1,4-dioxane T=160°C; 20 h;
参考文献
Goeminne, Annelies; Berg, Maya; McNaughton, Michael; Bal, Gunther; Surpateanu, Georgiana; Van der Veken, Pieter; Prol, Stijn De; Versees, Wim; Steyaert, Jan; Haemers, Achiel; Augustyns, Koen
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6752 - 6763
反应条件
1: With borane-THF in tetrahydrofuran T=0°C; 18 h; Inert atmosphere; 2: in tetrahydrofuran; methanol T=0°C; 1 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 76, # 21 p. 8658 - 8669
反应条件
1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere 2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 20 h / 80 °C / Inert atmosphere 3.1: borane-THF / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere 3.2: 1 h / 0 °C / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 21 p. 8658 - 8669
反应条件
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 20 h / 80 °C / Inert atmosphere 2.1: borane-THF / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 21 p. 8658 - 8669
