3-氨基-2-噻吩甲酸甲酯合成路线 （共 117 条）
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With bromine in tetrahydrofuran; hexane T=-78 - 20°C; 2.5 h;
参考文献
WO2010/101302 A1, ;
Page/Page column 130 ;
WO 2010/101302 A1
反应条件
MH2OH*HCl in acetonitrile 1.5 h; Heating;
参考文献
Synthetic Communications, , vol. 32, # 16 p. 2565 - 2568
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 76, p. 343 - 351
反应条件
sodium methylate in methanol
参考文献
Synthetic Communications, , vol. 44, # 7 p. 1002 - 1006
反应条件
hydrogenchloride; sodium tetrafluoroborate; diazonium fluoroborate; sodium nitrite Multistep reaction;
参考文献
Artuso, Emma; Barbero, Margherita; Degani, Iacopo; Dughera, Stefano; Fochi, Rita
Tetrahedron, 2006 , vol. 62, # 13 p. 3146 - 3157
反应条件
1: tetrafluoroboric acid; sodium nitrite / water / 0 - 5 °C 2: palladium diacetate / ethanol; water / 46 h / 60 °C View Scheme
参考文献
Raduan, Monica; Padrosa, Joaquim; Pla-Quintana, Anna; Parella, Teodor; Roglans, Anna
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2003 - 2012
反应条件
hydrogenchloride; sulfur dioxide; copper dichloride; sodium nitrite 1.) -5 deg C; Multistep reaction;
参考文献
Bastide; Badon; Cambon; Vega
Pesticide Science, 1994 , vol. 40, # 4 p. 293 - 297
反应条件
1: 68 percent / 1.) 6M HCl, NaNO2, 2.) 36.6percent HBF4 / H2O / 0 °C 2: 48 percent / xylene / 4 h / 150 - 160 °C 3: 100 percent / 1N NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Corral, Carlos; Lasso, Ana; Lissavetzky, Jaime; Alvarez-Insua, Alberto Sanchez; Valdeolmillos, Ana M.
Heterocycles, 1985 , vol. 23, # 6 p. 1431 - 1435
