3-氨基-2-噻吩甲酸甲酯合成路线

885698-98-64-(6-(溴甲基)-2-氯噻吩并[3,2-d]嘧啶-4-基)吗啉

参考文献

Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;

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Zhang, Mingzhu; Tamiya, Junko; Nguyen, Linh; Rowbottom, Martin W.; Dyck, Brian; Vickers, Troy D.; Grey, Jonathan; Schwarz, David A.; Heise, Christopher E.; Haelewyn, Jason; Mistry, Monica S.; Goodfellow, Val S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2535 - 2539

22288-78-43-氨基-2-噻吩甲酸甲酯+

76-05-1三氟乙酸

79128-68-03-(N-三氟乙酰氨基)噻吩-2-羧酸甲酯

参考文献

Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J.
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22288-78-43-氨基-2-噻吩甲酸甲酯

89283-80-73-硝基噻吩-2-羧酸

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Barker; Huddleston; Wood
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22288-78-43-氨基-2-噻吩甲酸甲酯

942589-44-85-碘-3-(2,2,2-三氟乙酰氨基)噻吩-2-羧酸甲酯

参考文献

Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1893 - 1901

108-31-6马来酸酐+

22288-78-43-氨基-2-噻吩甲酸甲酯

465514-23-23-(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)噻吩-2-羧酸甲酯

参考文献

Chen, Hai-Jun; Liu, Yong; Wang, Li-Na; Shen, Qiang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2876 - 2879

22288-78-43-氨基-2-噻吩甲酸甲酯

494833-79-33-氨基-5-溴噻吩-2-羧酰胺

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Takeda Pharmaceutical Company Limited
Patent: EP2540728 A1, 2013 ;

56489-01-13-氨基噻吩-2-甲醛

参考文献

Merck Frosst Canada, Inc.
Patent: US5374635 A1, 1994 ;

22288-78-43-氨基-2-噻吩甲酸甲酯

58231-00-83-氰基噻吩-2-羧酸

参考文献

Kaizerman, Jacob A.; Gross, Matthew I.; Ge, Yigong; White, Sarah; Hu, Wenhao; Duan, Jian-Xin; Baird, Eldon E.; Johnson, Kirk W.; Tanaka, Richard D.; Moser, Heinz E.; Buerli, Roland W.
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22288-78-43-氨基-2-噻吩甲酸甲酯

59337-94-9

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Unterhalt; Moghaddam
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