3-氨基-2-噻吩甲酸甲酯合成路线 （共 117 条）
反应条件
1.1: NO2(-); H(+) 1.2: 70 percent / CuCl 2.1: 96 percent / NaOH; water View Scheme
参考文献
Corral, Carlos; Lasso, Ana; Lissavetzky, Jaime; Alvarez-Insua, Alberto Sanchez; Valdeolmillos, Ana M.
Heterocycles, 1985 , vol. 23, # 6 p. 1431 - 1435
反应条件
1.1: cyanic acid sodium salt / water; acetic acid / 5 h / 20 °C 1.2: 0 °C 2.1: bromine / acetic acid / 30 h / 110 °C 3.1: N,N-diethylaniline; trichlorophosphate / 5 h / 150 °C View Scheme
参考文献
Korea Institute of Science and Technology
Patent: US2012/277424 A1, 2012 ;
反应条件
triethylamine in dichloromethane
参考文献
PFIZER INC.
Patent: EP807633 A2, 1997 ;
反应条件
1: 59 percent / hydrazine hydrate / butan-1-ol / 4 h / Heating 2: 8 percent / conc. HCl, sodium nitrite / H2O / 0.08 h 3: 70 percent / pyridine / 0.5 h View Scheme
参考文献
Huddleston, Patrick R.; Barker, John M.; Adamczewska, Yolante Z.; Wood, Michael L.; Holmes, David
Journal of Chemical Research, Miniprint, 1993 , # 2 p. 548 - 575
反应条件
1.1: NaNO2; glacial acetic acid; aq. HCl / 1 h / 0 °C 1.2: SO2; CuCl2 / acetic acid / 1 h / 0 °C 2.1: aq. NH3 / acetone / 1 h View Scheme
参考文献
Unterhalt; Moghaddam
Pharmazie, 1994 , vol. 49, # 2-3 p. 115 - 117
反应条件
1.1: NaNO2; HCl; HPF6 1.2: 47 percent / 180 - 200 °C 2.1: 79 percent / Br2; AlCl3; FeBr3 / CHCl3 / 17 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 50 p. 8797 - 8800
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in dichloromethane 16 h; 2: With sodium t-butanolate in dichloromethane 2 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/23707 A2, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/023707 A2
反应条件
1: 60 percent / glacial acetic acid / 120 h / Ambient temperature 2: 82 percent / H2NNH2 / methanol / 192 h / Ambient temperature View Scheme
参考文献
Hajjem, B.; Khoud, M. L. Ben; Baccar, B.
Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 6 p. 445 - 448
反应条件
1: 59 percent / hydrazine hydrate / butan-1-ol / 4 h / Heating 2: 8 percent / conc. HCl, sodium nitrite / H2O / 0.08 h View Scheme
参考文献
Huddleston, Patrick R.; Barker, John M.; Adamczewska, Yolante Z.; Wood, Michael L.; Holmes, David
Journal of Chemical Research, Miniprint, 1993 , # 2 p. 548 - 575
反应条件
4-(N,N-dimethlyamino)pyridine in hexane; dichloromethane; ethyl acetate
参考文献
Xenova Limited
Patent: US6218393 B1, 2001 ;
US 6218393 B1
