3-氨基-2-噻吩甲酸甲酯合成路线 （共 117 条）
反应条件
1: 59 percent / hydrazine hydrate / butan-1-ol / 4 h / Heating 2: 8 percent / conc. HCl, sodium nitrite / H2O / 0.08 h 3: 21 percent / phosphorus pentachloride, phosphoryl chloride / 1 h / Heating View Scheme
参考文献
Huddleston, Patrick R.; Barker, John M.; Adamczewska, Yolante Z.; Wood, Michael L.; Holmes, David
Journal of Chemical Research, Miniprint, 1993 , # 2 p. 548 - 575
反应条件
1: With sodium hydroxide; water 0.666667 h; Heating / reflux; 2: With hydrogenchloride in water pH=2;
参考文献
REPLIDYNE, INC.
Patent: WO2008/39639 A2, 2008 ;
Location in patent: Page/Page column 18 ;
参考文献
Naito, Youichiro; Akahoshi, Fumihiko; Takeda, Shinji; Okada, Takehiro; Kajii, Masahiko; Nishimura, Hiroko; Sugiura, Masanori; Fukaya, Chikara; Kagitani, Yoshio
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 3019 - 3029
反应条件
1: 59 percent / hydrazine hydrate / butan-1-ol / 4 h / Heating 2: 8 percent / conc. HCl, sodium nitrite / H2O / 0.08 h 3: 21 percent / phosphorus pentachloride, phosphoryl chloride / 1 h / Heating View Scheme
参考文献
Huddleston, Patrick R.; Barker, John M.; Adamczewska, Yolante Z.; Wood, Michael L.; Holmes, David
Journal of Chemical Research, Miniprint, 1993 , # 2 p. 548 - 575
反应条件
ammonium hydroxide; ammonium chloride 1680 h; Ambient temperature;
参考文献
Klemm, L. H.; Wang, Jun; Hawkins, Lucas
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 1039 - 1042
反应条件
4-(N,N-dimethlyamino)pyridine; sodium hydroxide; triethanolamine in methanol; acetone
参考文献
California Institute of Technology
Patent: US7452730 B2, 2008 ;
反应条件
1: 4-(N,N-dimethylamino)pyridine; triethylamine / acetone / 4 h 2: 0.79 g / NaOH / methanol / 4 h View Scheme
参考文献
Foister, Shane; Marques, Michael A.; Doss, Raymond M.; Dervan, Peter B.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4333 - 4340
反应条件
bromine; acetic acid T=20°C; 16.0833 h;
参考文献
LAILA NUTRACEUTICALS
Patent: US2010/68178 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 69 percent / CaCO3 / toluene / 0 to 5 deg C than reflux for 1.5 h 2: 59 percent / KH / toluene; dimethylformamide / 3 h / 70 °C 3: 82 percent / H2O; dimethylsulfoxide / 2 h / 150 °C View Scheme
参考文献
Kunick
Archiv der Pharmazie, 1991 , vol. 324, # 9 p. 579 - 581
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane T=20°C;
参考文献
AICURIS GMBH and CO. KG
Patent: WO2006/72347 A2, 2006 ;
Location in patent: Page/Page column 22 ;
