3-氨基-2-噻吩甲酸甲酯合成路线 (共 117 条)
反应条件
1: CH3COONH4 / Heating 2: HCOONH4; HCONH2 / 140 °C 3: oxalyl chloride / dimethylformamide View Scheme
参考文献
Yang, Beom-Seok; Kim, Yong-Zu; Park, Tae-Kyo; Woo, Sung-Ho; Lee, Hyang-Sook; Kim, Sun-Young; Cho, Jong-Un; Lee, Hong-Bum
Patent: US2013/72482 A1, 2013 ;
反应条件
pyridine T=0 - 20°C; 1 h;
参考文献
Wyeth
Patent: US2008/4325 A1, 2008 ;
Location in patent: Page/Page column 18 ;
US 20080004325 A1
参考文献
Englert, Lisa; Silber, Katrin; Steuber, Holger; Brass, Sascha; Over, Bjoern; Gerber, Hans-Dieter; Heine, Andreas; Diederich, Wibke E.; Klebe, Gerhard
ChemMedChem, 2010 , vol. 5, # 6 p. 930 - 940
反应条件
1: hydrogenchloride / 22 h / 20 - 100 °C / sealed tube; sonication 2: trichlorophosphate / 5 h / Reflux View Scheme
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; ALVAREZ ESCOBAR, Rosa Maria; RIESCO FAGUNDO, Rosario Concepcion; GARCIA GARCIA, Ana Belen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; BLANCO APARICIO, Carmen; CEBRIAN MUNOZ, David Alvaro
Patent: WO2012/156756 A2, 2012 ;
WO 2012/156756 A2
反应条件
1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / |Inert atmosphere 2: water / acetonitrile / |Alkaline conditions; |Inert atmosphere 3: thionyl chloride / |Inert atmosphere View Scheme
参考文献
Iaroshenko, Viktor O.; Ali, Sajid; Babar, Tariq Mahmood; Abbasi, Muhammad S.A.; Sosnovskikh, Vyacheslav Ya; Villinger, Alexander; Tolmachev, Andrey; Langer, Peter
Tetrahedron, 2013 , vol. 69, # 15 p. 3167 - 3181
反应条件
sodium hydroxide; oxalic acid 1.) reflux, 30 min, 2.) n-propanol, 38 deg C, 45 min; Yield given. Multistep reaction;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/147952 A1, 2008 ;
Location in patent: Page/Page column 49-50 ;
WO 2008/147952 A1
反应条件
triethylamine in tetrahydrofuran T=20°C;
参考文献
Jung, Seo Hee; Suh, Ji Hee; Kim, Eun Hee; Kim, Jun Tae; Yoo, Seung-Eun; Kang, Nam Sook
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5155 - 5164
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 60, # 8 p. 1037 - 1045
反应条件
acetic acid in water T=25°C; 5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 20 p. 6614 - 6618
反应条件
1: With cyanic acid sodium salt in water; acetic acid T=20°C; 5 h; 2: With sodium hydroxide in water T=0°C;
参考文献
WO2011/49332 A2, ;
Page/Page column 16 ;
WO 2011/049332 A2