3-氨基-2-噻吩甲酸甲酯合成路线 （共 117 条）
反应条件
acetic acid 5 h; Ambient temperature;
参考文献
Nucleosides and Nucleotides, , vol. 13, # 4 p. 925 - 937
参考文献
US2010/233164 A1, ;
US 20100233164 A1
反应条件
1: With tert.-butylnitrite; copper(ll) bromide in acetonitrile T=0 - 20°C; 2 h; Inert atmosphere; 2: With hydrogenchloride in water; acetonitrile Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 53, # 52 p. 7135 - 7139
反应条件
ammonia in methanol T=130°C; 7 h;
参考文献
Ube Industries, Ltd.
Patent: EP1637523 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
1: formic acid With acetic anhydride 2: methyl 3-aminothiophene-2-carboxylate T=20°C; 3 h; 3: With ammonium formate in formamide T=20 - 150°C; 20 h;
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;
Location in patent: Page/Page column 19 ;
反应条件
1: formic acid; methyl 3-aminothiophene-2-carboxylate With acetic anhydride T=20°C; 3 h; 2: ammonium formate; formamide T=20 - 150°C; 20 h;
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 28 ;
参考文献
MethylGene, Inc.
Patent: US2005/288282 A1, 2005 ;
反应条件
formamide in dichloromethane
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
参考文献
HANMI PHARM CO., LTD.; SON, Jung Beom; KIM, Nam Du; CHANG, Young Kil; KIM, Hee Cheol; KIM, Ji Sook; JUNG, Young Hee
Patent: WO2012/93809 A2, 2012 ;
Location in patent: Page/Page column 22 ;
WO 2012/093809 A2
反应条件
in 2-methoxy-ethanol 3 h; Heating / reflux;
参考文献
US2003/225111 A1, ;
Page 50, 51 ;
