3-(乙酰基氨基)-2-噻吩羧酸甲酯合成路线 （共 9 条）
反应条件
pyridine T=0 - 20°C; 1 h;
参考文献
Wyeth
Patent: US2008/4325 A1, 2008 ;
Location in patent: Page/Page column 18 ;
US 20080004325 A1
参考文献
Englert, Lisa; Silber, Katrin; Steuber, Holger; Brass, Sascha; Over, Bjoern; Gerber, Hans-Dieter; Heine, Andreas; Diederich, Wibke E.; Klebe, Gerhard
ChemMedChem, 2010 , vol. 5, # 6 p. 930 - 940
反应条件
pyridine hydrochloride reflux, 22h; Yield given. Multistep reaction;
参考文献
Coutts, Ian G. C.; Edwards, Mark; Richards, David J.
Synthesis, 1981 , # 6 p. 487 - 489
反应条件
1: HNO3; H2SO4
2: HBr
View Scheme
参考文献
Jarvest, Richard L.; Connor, Susan C.; Gorniak, Joselina G.; Jennings, L. John; Serafinowska, Halina T.; West, Andrew
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1733 - 1738
反应条件
sulfuric acid; nitric acid
T=-25 - 0°C;
参考文献
Sauter, Guido; Stulz, Eugen; Leumann, Christian
Helvetica Chimica Acta, 1998 , vol. 81, # 1 p. 14 - 34
反应条件
sulfuric acid; nitric acid
T=-25 - 0°C;
参考文献
Sauter, Guido; Stulz, Eugen; Leumann, Christian
Helvetica Chimica Acta, 1998 , vol. 81, # 1 p. 14 - 34
反应条件
sulfuric acid; nitric acid
T=-30 - -25°C;
参考文献
Jarvest, Richard L.; Connor, Susan C.; Gorniak, Joselina G.; Jennings, L. John; Serafinowska, Halina T.; West, Andrew
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1733 - 1738
反应条件
1: HNO3, H2SO4 / -30 °C
2: sodium methylate / methanol
3: hydrogen
4: pyridine / CHCl3
5: 75 percent / LiAlH4 / tetrahydrofuran / 0 °C
6: 80 percent / pyridinium chlorochromate / CH2Cl2
View Scheme
参考文献
Rossy; Vogel; Hoffman; et al.
Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3493 - 3496
反应条件
1: 35 percent / 95percent H2SO4-100percent HNO3 / -25 - 0 °C
2: 80 percent / MeONa / methanol / 1 h / 55 - 60 °C
View Scheme
参考文献
Rossy; Vogel; Hoffman; et al.
Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3493 - 3496
