2-甲基咪唑并[1,2-a]吡啶-3-甲酰胺合成路线 （共 10 条）
反应条件
sodium hydroxide; hydrogen; nickel in methanol Ambient temperature;
参考文献
Buzas, A.; Merour, J. Y.
Synthesis, 1989 , # 6 p. 458 - 461
反应条件
sodium hydroxide; hydrogen; nickel in methanol Ambient temperature;
参考文献
Buzas, A.; Merour, J. Y.
Synthesis, 1989 , # 6 p. 458 - 461
反应条件
1: 80 percent / piperidine / 5 h / Heating 2: 65 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature 3: 20 percent / NaH / tetrahydrofuran 4: 83 percent / H2, Raney-Ni, NaOH / methanol / Ambient temperature View Scheme
参考文献
Synthesis, , # 6 p. 458 - 461
反应条件
1: 65 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature 2: 20 percent / NaH / tetrahydrofuran 3: 83 percent / H2, Raney-Ni, NaOH / methanol / Ambient temperature View Scheme
参考文献
Synthesis, , # 6 p. 458 - 461
反应条件
1: 80 percent / piperidine / 5 h / Heating 2: 65 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature 3: 20 percent / NaH / tetrahydrofuran 4: 83 percent / H2, Raney-Ni, NaOH / methanol / Ambient temperature View Scheme
参考文献
Synthesis, , # 6 p. 458 - 461
反应条件
1: diethyl ether / 1.5 h / Ambient temperature 2: 96 percent / Et3N / tetrahydrofuran / 3 h / 0 °C 3: 96 percent / LiAlH4, AlCl3 / tetrahydrofuran / 2 h, 0 deg C; 5 h, RT 4: 1.) TFA, 2.) hydrogen / 2.) 20 percent palladium hydroxide on carbon / 1.) benzene, 1 d, 2.) EtOAc, RT, 48 h View Scheme
参考文献
Heterocycles, , vol. 50, # 2 p. 1033 - 1039
反应条件
1: 96 percent / Et3N / tetrahydrofuran / 3 h / 0 °C 2: 96 percent / LiAlH4, AlCl3 / tetrahydrofuran / 2 h, 0 deg C; 5 h, RT 3: 1.) TFA, 2.) hydrogen / 2.) 20 percent palladium hydroxide on carbon / 1.) benzene, 1 d, 2.) EtOAc, RT, 48 h View Scheme
参考文献
Heterocycles, , vol. 50, # 2 p. 1033 - 1039
反应条件
1: 96 percent / LiAlH4, AlCl3 / tetrahydrofuran / 2 h, 0 deg C; 5 h, RT 2: 1.) TFA, 2.) hydrogen / 2.) 20 percent palladium hydroxide on carbon / 1.) benzene, 1 d, 2.) EtOAc, RT, 48 h View Scheme
参考文献
Heterocycles, , vol. 50, # 2 p. 1033 - 1039
反应条件
1: 20 percent / NaH / tetrahydrofuran 2: 83 percent / H2, Raney-Ni, NaOH / methanol / Ambient temperature View Scheme
参考文献
Synthesis, , # 6 p. 458 - 461
反应条件
hydrogen; trifluoroacetic acid; palladium dihydroxide 1.) benzene, 1 d, 2.) EtOAc, RT, 48 h; Yield givenMultistep reaction;
参考文献
Heterocycles, , vol. 50, # 2 p. 1033 - 1039
