反应条件
1.1: 90 percent / Et3N; DMSO; pyridine*SO3 / CH2Cl2 / 2 h / 5 - 20 °C 2.1: EtMgBr / CH2Cl2 / 3 h / 20 °C 2.2: 98 percent / CH2Cl2 / 2 h / -78 - 20 °C 3.1: 100 percent / pyridine / dimethylformamide / 3 h 4.1: ethyl acetate / 60 °C 5.1: 0.838 g / MeOH / 1 h / Heating 6.1: 91 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
DeSolms, S. Jane; Ciccarone, Terrence M.; MacTough, Suzanne C.; Shaw, Anthony W.; Buser, Carolyn A.; Ellis-Hutchings, Michelle; Fernandes, Christine; Hamilton, Kelly A.; Huber, Hans E.; Kohl, Nancy E.; Lobell, Robert B.; Robinson, Ronald G.; Tsou, Nancy N.; Walsh, Eileen S.; Graham, Samuel L.; Beese, Lorena S.; Taylor, Jeffrey S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 2973 - 2984