2,2-二甲基-5-(1-甲基亚乙基)-1,3-二噁烷-4,6-二酮合成路线 （共 13 条）
反应条件
piperidine; acetic acid T=20 - 25°C; 18 h; Inert atmosphereMolecular sieve;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FANDRICK, Daniel Robert; YEE, Nathan; SONG, Jinhua J.; REEVES, Jonathan Timothy
Patent: WO2010/141334 A1, 2010 ;
Location in patent: Page/Page column 13-14 ;
反应条件
1: in tert-butyl alcohol 5 h; Heating / reflux; 2: With ammonia in ethanol; water T=0°C;
参考文献
Ratiopharm GmbH
Patent: EP1705175 A1, 2006 ;
Location in patent: Page/Page column 5; 17 ;
反应条件
ethylenediamine diacetic acid in ethanol T=20°C; Knoevenagel condensation; Title compound not separated from byproducts;
参考文献
Snider, Barry B.; Smith, Rachel B.
Tetrahedron, 2002 , vol. 58, # 1 p. 25 - 34
参考文献
Ratiopharm GmbH
Patent: EP1834944 A1, 2007 ;
Location in patent: Page/Page column 5 ;
反应条件
in isopropyl alcohol
参考文献
Tararov, Vitali I.; Korostylev, Andrei; Koenig, Gerd; Boerner, Armin
Synthetic Communications, 2006 , vol. 36, # 2 p. 187 - 191
反应条件
1.1: CuCN / tetrahydrofuran; diethyl ether / 0 - 20 °C 1.2: 66 percent / tetrahydrofuran / 16 h / 20 °C 2.1: conc. HCl / dioxane / 18 h / Heating 3.1: 10.2 g / 1 h / 200 °C View Scheme
参考文献
Vogt; Molino; Robichaud
Synthetic Communications, 2001 , vol. 31, # 5 p. 679 - 684
反应条件
sodium hydrogen telluride in ethanol
1.5 h; Heating;
参考文献
Huang, Xian; Xie, Linghong
Synthetic Communications, 1986 , vol. 16, # 13 p. 1701 - 1708
反应条件
1: N-bromo-succinimide / CCl4 / 10 h / Irradiation; ice-bath cooling
2: K2CO3 / tetrahydrofuran; H2O
View Scheme
参考文献
Hunter, Norman R.; Green, Nancy A.; McKinnon, David M.
Tetrahedron Letters, 1980 , vol. 21, # 48 p. 4589 - 4592
反应条件
copper(l) chloride in diethyl ether
T=-15 - 20°C; 1.25 h;
参考文献
Huang, Xian; Chan, Cheng-Chu; Wu, Quin-Li
Tetrahedron Letters, 1982 , vol. 23, p. 75 - 76
反应条件
T=430°C; P=1E-05 - 0.0001 Torr; flasc-vacuum pyrolysis; Product distribution;
参考文献
Wentrup,C.; Lorencak,P.
Journal of the American Chemical Society, 1988 , vol. 110, p. 1880
