2-氨基-N-间甲苯苯甲酰胺合成路线 （共 8 条）
反应条件
5 h; Heating / reflux;
参考文献
Hydra Biosciences, Inc.
Patent: US2007/179164 A1, 2007 ;
Location in patent: Page/Page column 50; 51 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
P=750.075 Torr;
参考文献
Kakuta, Hiroki; Zheng, Xiaoxia; Oda, Hiroyuki; Harada, Shun; Sugimoto, Yukio; Sasaki, Kenji; Tai, Akihiro
Journal of Medicinal Chemistry, 2008 , vol. 51, # 8 p. 2400 - 2411
反应条件
benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine in N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US5631280 A1, 1997 ;
US 5631280 A
参考文献
Osman; El-Gendy; Omar; Wagdy
Bollettino Chimico Farmaceutico, 2002 , vol. 141, # 1 p. 8 - 14
反应条件
1: 60 percent / aq. K2CO3 / tetrahydrofuran / 12 h / Heating
2: 53 percent / H2 / 5percent Pd/C / 3 h / 2327.2 Torr
View Scheme
参考文献
Clark; Lin; Sansom
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1534 - 1537
反应条件
1: 60 percent / aq. K2CO3 / tetrahydrofuran / 12 h / Heating
2: 53 percent / H2 / 5percent Pd/C / 3 h / 2327.2 Torr
View Scheme
参考文献
Clark; Lin; Sansom
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1534 - 1537
反应条件
in diethyl ether
T=0 - 10°C; 0.5 h;
参考文献
Mahiwal, Kuldeep; Kumar, Pradeep; Narasimhan, Balasubramanian
Medicinal Chemistry Research, 2012 , vol. 21, # 3 p. 293 - 307
反应条件
1: thionyl chloride / 4.5 h / 80 °C
2: diethyl ether / 0.5 h / 0 - 10 °C
View Scheme
参考文献
Mahiwal, Kuldeep; Kumar, Pradeep; Narasimhan, Balasubramanian
Medicinal Chemistry Research, 2012 , vol. 21, # 3 p. 293 - 307
