顺-1-(Boc-氨基)-4-(羟甲基)环己烷合成路线 （共 9 条）
反应条件
1: With triethylamine in chloroform T=20°C; 5 h; 2: With lithium aluminium tetrahydride in diethyl ether T=20°C; 2 h;
参考文献
Taisho Pharmaceutical Co. Ltd.; Arena Pharmaceuticals, Inc.
Patent: EP1464335 A2, 2004 ;
Location in patent: Page/Page column 165 ;
EP 1464335 A2
反应条件
in tetrahydrofuran T=20°C;
参考文献
Almirall, S.A.; Eastwood, Paul Robert; Bach Taña, Jordi; Pages Santacana, Lluis Miquel
Patent: EP2554544 A1, 2013 ;
Location in patent: Paragraph 0161 ;
反应条件
lithium aluminium tetrahydride in diethyl ether T=-4 - 20°C; 2 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc
Patent: WO2005/95357 A2, 2005 ;
Location in patent: Page/Page column 109; 110 ;
WO 2005/095357 A2
反应条件
1: thionyl chloride / 4.5 h / 20 °C 2: 531 g / triethylamine / CHCl3 / 5 h / 20 °C 3: 301 g / lithium aluminum hydride / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Witherington, Jason; Bordas, Vincent; Cooper, Dave G.; Forbes, Ian T.; Gribble, Andrew D.; Ife, Robert J.; Berkhout, Theo; Gohil, Jayneeta; Groot, Pieter H.E.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 16 p. 2177 - 2180
反应条件
1: 531 g / triethylamine / CHCl3 / 5 h / 20 °C 2: 301 g / lithium aluminum hydride / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Kanuma, Kosuke; Omodera, Katsunori; Nishiguchi, Mariko; Funakoshi, Takeo; Chaki, Shigeyuki; Nagase, Yasuko; Iida, Izumi; Yamaguchi, Jun-ichi; Semple, Graeme; Tran, Thuy-Anh; Sekiguchi, Yoshinori
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 10 p. 3307 - 3319
反应条件
1: 100 percent / TEA 2: TEA 3: NaBH4 View Scheme
参考文献
Witherington, Jason; Bordas, Vincent; Cooper, Dave G.; Forbes, Ian T.; Gribble, Andrew D.; Ife, Robert J.; Berkhout, Theo; Gohil, Jayneeta; Groot, Pieter H.E.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 16 p. 2177 - 2180
反应条件
1: TEA 2: NaBH4 View Scheme
参考文献
Witherington, Jason; Bordas, Vincent; Cooper, Dave G.; Forbes, Ian T.; Gribble, Andrew D.; Ife, Robert J.; Berkhout, Theo; Gohil, Jayneeta; Groot, Pieter H.E.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 16 p. 2177 - 2180
反应条件
oxalyl dichloride; TEA; dimethyl sulfoxide
参考文献
Witherington, Jason; Bordas, Vincent; Cooper, Dave G.; Forbes, Ian T.; Gribble, Andrew D.; Ife, Robert J.; Berkhout, Theo; Gohil, Jayneeta; Groot, Pieter H.E.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 16 p. 2177 - 2180
反应条件
1: 27.5 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 60 h / 20 °C
2: hydrazine hydrate / ethanol / 2.25 h / Heating
View Scheme
参考文献
Kanuma, Kosuke; Omodera, Katsunori; Nishiguchi, Mariko; Funakoshi, Takeo; Chaki, Shigeyuki; Nagase, Yasuko; Iida, Izumi; Yamaguchi, Jun-ichi; Semple, Graeme; Tran, Thuy-Anh; Sekiguchi, Yoshinori
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 10 p. 3307 - 3319
