1,3-二甲基-9h-吡啶并[3,4-b]吲哚合成路线 （共 9 条）
反应条件
ammonium acetate in acetic acid
T=60°C;
参考文献
Duval, Eric; Cuny, Gregory D.
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5411 - 5413
反应条件
bis-triphenylphosphine-palladium(II) chloride; cesium fluoride in N,N-dimethyl-formamide
T=100°C; 14 h; Inert atmosphereSealed vessel;
参考文献
Chughtai, Majid; Eagan, James M.; Padwa, Albert
Synlett, 2011 , # 2 art. no. G26310ST, p. 215 - 218
反应条件
1: 43 percent / ZnCl2 / diethyl ether / 0.75 h / 0 - 20 °C
2: 85 percent / ammonium acetate / acetic acid / 60 °C
View Scheme
参考文献
Duval, Eric; Cuny, Gregory D.
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5411 - 5413
反应条件
1.1: isobutyl chloroformate; NMM / tetrahydrofuran / 0.33 h / -20 °C
1.2: 84 percent / Et3N / dimethylformamide; tetrahydrofuran / 1 h / 0 °C
2.1: 87 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C
3.1: 43 percent / ZnCl2 / diethyl ether / 0.75 h / 0 - 20 °C
4.1: 85 percent / ammonium acetate / acetic acid / 60 °C
View Scheme
参考文献
Duval, Eric; Cuny, Gregory D.
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5411 - 5413
反应条件
1: 87 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 43 percent / ZnCl2 / diethyl ether / 0.75 h / 0 - 20 °C
3: 85 percent / ammonium acetate / acetic acid / 60 °C
View Scheme
参考文献
Duval, Eric; Cuny, Gregory D.
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5411 - 5413
反应条件
1: pyridine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
2: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 30 h / 20 °C / Inert atmosphere
3: bis-triphenylphosphine-palladium(II) chloride; cesium fluoride / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere; Sealed vessel
View Scheme
参考文献
Chughtai, Majid; Eagan, James M.; Padwa, Albert
Synlett, 2011 , # 2 art. no. G26310ST, p. 215 - 218
反应条件
1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere
2: pyridine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
3: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 30 h / 20 °C / Inert atmosphere
4: bis-triphenylphosphine-palladium(II) chloride; cesium fluoride / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere; Sealed vessel
View Scheme
参考文献
Chughtai, Majid; Eagan, James M.; Padwa, Albert
Synlett, 2011 , # 2 art. no. G26310ST, p. 215 - 218
反应条件
1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 30 h / 20 °C / Inert atmosphere
2: bis-triphenylphosphine-palladium(II) chloride; cesium fluoride / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere; Sealed vessel
View Scheme
参考文献
Chughtai, Majid; Eagan, James M.; Padwa, Albert
Synlett, 2011 , # 2 art. no. G26310ST, p. 215 - 218
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 0.17 h / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere
3.1: pyridine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
4.1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 30 h / 20 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; cesium fluoride / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere; Sealed vessel
View Scheme
参考文献
Chughtai, Majid; Eagan, James M.; Padwa, Albert
Synlett, 2011 , # 2 art. no. G26310ST, p. 215 - 218
