(S)-(+)-1,2-异亚丙基甘油合成路线 (共 82 条)
反应条件
pyridine T=0 - 20°C;
参考文献
Dams, Iwona; Chodynski, Michal; Krupa, Malgorzata; Pietraszek, Anita; Zezula, Marta; Cmoch, Piotr; Kosinska, Monika; Kutner, Andrzej
Tetrahedron, 2013 , vol. 69, # 5 p. 1634 - 1648
参考文献
Tsuda, Yoshisuke; Yoshimoto, Kimihiro; Nishikawa, Terumi
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 12 p. 3593 - 3600
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C; 4 h;
参考文献
Fujifilm Corporation
Patent: EP1795208 A1, 2007 ;
Location in patent: Page/Page column 13-14 ;
反应条件
potassium hydroxide; 18-crown-6 ether in tetrahydrofuran T=20°C; benzylation;
参考文献
Xia, Jie; Hui, Yong-Zheng
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1659 - 1663
反应条件
ethylene glycol dimethyl ether; naphthalene; sodium Erwaermen des Reaktionsgemisches mit Benzylbromid;
参考文献
Sowden; Fischer
Journal of the American Chemical Society, 1941 , vol. 63, p. 3244,3245
Full Text Show Details
Baer; Buchnea
Journal of Biological Chemistry, 1958 , vol. 230, p. 447,449
参考文献
Barrett, Stephen Douglas; Biwersi, Cathlin Marie; Chen, Michael Huai Gu; Kaufman, Michael David; Tecle, Haile; Warmus, Joseph Scott
Patent: US2004/54172 A1, 2004 ;
反应条件
1: With di-isopropyl azodicarboxylate; N-hydroxyphthalimide resin; triphenylphosphine; 1H-imidazole in dichloromethane T=20°C; Mitsunobu reaction; 24 h; 2: With methylamine in methanol; chloroform T=20°C; 2 h;
参考文献
Maillard, Ludovic T.; Benohoud, Meryem; Durand, Philippe; Badet, Bernard
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6303 - 6312
参考文献
Barrett, Stephen Douglas; Biwersi, Cathlin Marie; Chen, Michael Huai Gu; Kaufman, Michael David; Tecle, Haile; Warmus, Joseph Scott
Patent: US2004/54172 A1, 2004 ;
反应条件
1: triethylamine / dichloromethane / 8 h
2: sodium azide / N,N-dimethyl-formamide / 20 h / 65 °C
3: triphenylphosphine / water; tetrahydrofuran
View Scheme
参考文献
Doboszewski, Bogdan; Groaz, Elisabetta; Herdewijn, Piet
European Journal of Organic Chemistry, 2013 , # 22 p. 4804 - 4815
反应条件
1: 70 percent / pyridine
2: 40 percent / NaN3 / dimethylformamide / 12 h / 60 °C
View Scheme
参考文献
Lepine, Renaud; Carbonnelle, Anny-Claude; Zhu, Jieping
Synlett, 2003 , # 10 p. 1455 - 1458