2-巯基-4,6-二甲基嘧啶水合物合成路线 （共 27 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Song, Rui-Feng; Xie, Ya-Bo; Bu, Xian-He
Journal of Molecular Structure, 2003 , vol. 657, # 1-3 p. 311 - 316
反应条件
1: 2-mercapto-4,6-dimethyl-pyrimidine With hydrogenchloride; sodium hypochlorite in dichloromethane; water T=-10 - -5°C; 0.25 h; 2: benzylamine in dichloromethane T=0°C; 0.5 h;
参考文献
Wright, Stephen W.; Hallstrom, Kelly N.
Journal of Organic Chemistry, 2006 , vol. 71, # 3 p. 1080 - 1084
反应条件
1: 89.7 percent / aq. NaOH / 7 h / Ambient temperature 2: 34.9 percent / 30percent aq. H2O2, HCOOH / 3 h / Ambient temperature 3: 65 percent / ethanol / 1.) ice bath, 2.) room temperature View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
1: With hydrogenchloride; sodium hypochlorite; calcium chloride in dichloromethane; water T=-23°C; 0.25 h; 2: With ammonia in dichloromethane T=-70 - 20°C; 16.25 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/130057 A1, 2009 ;
Location in patent: Page/Page column 58 ;
US 20090130057 A1
反应条件
sodium hydroxide in water T=20°C; 1.16667 h;
参考文献
Abbott GmbH and Co., KG
Patent: US6670367 B1, 2003 ;
Location in patent: Page column 15 ;
反应条件
sodium hydroxide 7 h; Ambient temperature;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
tetrabutylammomium bromide; potassium carbonate T=90°C; P=760.051 Torr; 1 h;
参考文献
Xie, Jian-Gang; Quan, Jing; Li, Shu-Bai; Zheng, Yan; Zhu, Li-Min
Synthetic Communications, 2011 , vol. 41, # 6 p. 871 - 878
参考文献
Hale; Williams
Journal of the American Chemical Society, 1915 , vol. 37, p. 598
反应条件
sodium hypochlorite; KHF2; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane; water T=-5 - 0°C; 0.666667 h;
参考文献
Wright, Stephen W.; Hallstrom, Kelly N.
Journal of Organic Chemistry, 2006 , vol. 71, # 3 p. 1080 - 1084
参考文献
Cranham et al.
Journal of the Science of Food and Agriculture, 1958 , vol. 9, p. 147
