4-(2-(氮杂环庚烷-1-基)乙氧基)苯甲醛合成路线 （共 4 条）
反应条件
1: p-hydroxybenzaldehyde hydrochloride With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: 1-chloro-2-(perhydroazepin-1-yl)ethane hydrochloride With potassium carbonate in N,N-dimethyl-formamide 1 h;
参考文献
Wyeth
Patent: EP1212335 B1, 2006 ;
Location in patent: Page/Page column 24 ;
EP 1212335 B1
反应条件
1: azacycloheptane With potassium carbonate in acetone 2 h; Inert atmosphereReflux; 2: 4-(2-bromoethoxy)benzaldehyde With potassium iodide in acetone Inert atmosphereReflux;
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
1.1: potassium carbonate / acetone / Heating 2.1: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux 2.2: Inert atmosphere; Reflux View Scheme
参考文献
Manohar, Sunny; Khan, Shabana I.; Kandi, Shamseer Kulangara; Raj, Kranthi; Sun, Guojing; Yang, Xiaochuan; Calderon Molina, Angie D.; Ni, Nanting; Wang, Binghe; Rawat, Diwan S.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 112 - 116
反应条件
sodium tetrahydroborate in methanol T=0 - 5°C; 0.5 h;
参考文献
Wyeth
Patent: EP1212335 B1, 2006 ;
Location in patent: Page/Page column 25 ;
EP 1212335 B1
