(4-(2-(氮杂环庚烷-1-基)乙氧基)苯基)甲醇合成路线 （共 10 条）
反应条件
sodium tetrahydroborate in methanol T=0 - 5°C; 0.5 h;
参考文献
Wyeth
Patent: EP1212335 B1, 2006 ;
Location in patent: Page/Page column 25 ;
EP 1212335 B1
反应条件
sodium hydroxide; tetrabutylammomium bromide in water; toluene Reflux;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
Location in patent: Page/Page column 4; 22; 23 ;
反应条件
1: NaBH4 / methanol / 20 °C 2: tetrahydrofuran / Heating View Scheme
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
potassium carbonate; caesium carbonate in acetonitrile T=90°C; 24 h;
参考文献
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798
Angew. Chem., 2013 , p. 5999
反应条件
1: K2CO3 / dimethylformamide / 120 °C 2: NaBH4 / methanol / 20 °C 3: tetrahydrofuran / Heating View Scheme
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
in tetrahydrofuran Heating;
参考文献
Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893
反应条件
1: With hydrogenchloride in tetrahydrofuran T=0°C; 2: With thionyl chloride in tetrahydrofuran T=50°C;
参考文献
Wyeth
Patent: EP1159267 B1, 2004 ;
Location in patent: Page 11 ;
反应条件
1: With hydrogenchloride in tetrahydrofuran 2: With thionyl chloride in tetrahydrofuran T=0 - 50°C; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
Location in patent: Page/Page column 4; 24 ;
反应条件
1.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 2.2: 5 °C 3.1: hydrogen / palladium 10 on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
反应条件
1.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C
2.2: 5 °C
View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
