1-(2-(4-(氯甲基)苯氧基)乙基)氮杂烷盐酸盐合成路线 （共 7 条）
反应条件
1: With hydrogenchloride in tetrahydrofuran 2: With thionyl chloride in tetrahydrofuran T=0 - 50°C; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
Location in patent: Page/Page column 4; 24 ;
反应条件
thionyl chloride T=50°C;
参考文献
Wyeth
Patent: EP1212335 B1, 2006 ;
Location in patent: Page/Page column 25 ;
EP 1212335 B1
反应条件
1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / Reflux 2: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere View Scheme
参考文献
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798
Angew. Chem., 2013 , p. 5999
反应条件
1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / Reflux 2: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
反应条件
1: potassium carbonate; caesium carbonate / acetonitrile / 24 h / 90 °C 2: thionyl chloride / tetrahydrofuran / 6 h / |Reflux View Scheme
参考文献
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798
Angew. Chem., 2013 , p. 5999
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 1.2: 5 °C 2.1: hydrogen / palladium 10 on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna
Patent: WO2011/22596 A2, 2011 ;
反应条件
1: 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole With sodium hydride in N,N-dimethyl-formamide
T=0 - 5°C; Inert atmosphere;
2: 1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride in N,N-dimethyl-formamide
Inert atmosphere;
参考文献
Jirman, Josef; Richter, Jindrich
Patent: US2010/240888 A1, 2010 ;
Location in patent: Page/Page column 3 ;
