(s)-哌啶-2-羧酸乙酯合成路线 （共 5 条）
反应条件
1: (-)-(S)-pipecolic acid With thionyl chloride
T=20 - 23°C; 16 h; Inert atmosphere;
2: ethanol 6 h; Inert atmosphere;
参考文献
Alvarez-Ibarra, Carlos; Lujan, Juan F. Collados; Quiroga-Feijoo, Maria L.
Tetrahedron Asymmetry, 2010 , vol. 21, # 19 p. 2334 - 2345
反应条件
potassium tert-butylate in dichloromethane
8 h; Inert atmosphere;
参考文献
Mahdi, Tayseer; Del Castillo, Jon Nathaniel; Stephan, Douglas W.
Organometallics, 2013 , vol. 32, # 6 p. 1971 - 1978
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane
T=23°C; 18 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Binanzer, Michael; Hsieh, Sheng-Ying; Bode, Jeffrey W.
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19698 - 19701
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate
T=23°C; 24 h; Resolution of racemate;
参考文献
Hsieh, Sheng-Ying; Binanzer, Michael; Kreituss, Imants; Bode, Jeffrey W.
Chemical Communications, 2012 , vol. 48, # 71 p. 8892 - 8894
反应条件
in dichloromethane
T=23°C; 48 h; aminomethyl polystyrene resin; Inert atmosphereResolution of racemate;
参考文献
Kreituss, Imants; Murakami, Yuta; Binanzer, Michael; Bode, Jeffrey W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10660 - 10663
Angew. Chem., 2012 , vol. 124, # 42 p. 10815 - 10819,5
