3,5-二甲基-4-羟基苯甲醛合成路线 （共 59 条）
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; 1,3-dimethyl-5-ethyl-4a-hydroperoxyalloxazine; oxygen; sodium hydrogencarbonate in water; acetonitrile T=20°C; Dakin Phenol Oxidation; 3 h;
参考文献
Organic Letters, , vol. 14, # 19 p. 5150 - 5153,4
反应条件
1: potassium carbonate / ethanol / 24 h / |Reflux 2: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 150 °C View Scheme
反应条件
potassium carbonate in acetone T=50°C; 2.5 h;
参考文献
GENFIT
Patent: US2006/79696 A1, 2006 ;
Location in patent: Page/Page column 45 ;
US 20060079696 A1
反应条件
potassium carbonate in acetonitrile
参考文献
Warner-Lambert Co.
Patent: US5166398 A1, 1992 ;
反应条件
hydroxylamine hydrochloride; sodium acetate in water
T=80°C; 2 h;
参考文献
Ley, Jakob P; Bertram, Heinz-Juergen
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 7 p. 1879 - 1885
反应条件
piperidine in ethanol
参考文献
Hansen, Birgit Sehested; Hansen, Thomas Kruse; Tullin, Soren; Colding-Jorgensen, Morten
Patent: US2004/138301 A1, 2004 ;
反应条件
1: K2CO3 / acetonitrile / 60 °C
2: Na2CO3; KI / butan-1-ol / 95 °C
View Scheme
参考文献
Lee-Dutra, Alice; Arienti, Kristen L.; Buzard, Daniel J.; Hack, Michael D.; Khatuya, Haripada; Desai, Pragnya J.; Nguyen, Steven; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.; Breitenbucher, J. Guy
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6043 - 6048
反应条件
pyridine; acetic anhydride in dichloromethane
参考文献
Dawson, Marcia J.; Fontana, Joseph A.; Zhang, Xiao-kun; Leid, Mark; Jong, Ling; Hobbs, Peter D.
Patent: US2003/176506 A1, 2003 ;
反应条件
diethylazodicarboxylate in tetrahydrofuran; hexane
参考文献
Advanced Medicine, Inc.
Patent: US6420354 B1, 2002 ;
US 6420354 B1
