1: sodium hydrogencarbonate / acetonitrile / 7 h / 30 °C / Inert atmosphere; Reflux; Large scale reaction 2: hydrogenchloride / dichloromethane / 0.5 h / Large scale reaction View Scheme

hydrogenchloride in dichloromethane 0.5 h; Large scale reaction;

1: water / 13 h / 0 - 5 °C / Large scale reaction 2: sodium hydrogencarbonate / acetonitrile / 7 h / 30 °C / Inert atmosphere; Reflux; Large scale reaction 3: hydrogenchloride / dichloromethane / 0.5 h / Large scale reaction View Scheme

10 palladium on activated charcoal; hydrogen in ethanol; water T=20°C; P=2585.81 Torr; 24 h; Large scale reaction;