(R)-(+)-α,α-二苯基脯氨醇合成路线 (共 61 条)
反应条件
in tetrahydrofuran 16 h; Ambient temperature;
参考文献
Corey, E.J.; Shibata, Saizo; Bakshi, Raman K.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2861 - 2863
反应条件
1: 96 percent / 2M NaOH / H2O / 2 h / -5 - 0 °C 2: 35.9 g / boron trifluoride etherate / 1 h / Heating 3: 52.7 percent / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 12 p. 2861 - 2863
反应条件
1: 35.9 g / boron trifluoride etherate / 1 h / Heating 2: 52.7 percent / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 12 p. 2861 - 2863
反应条件
in tetrahydrofuran T=-15°C; 3 h; variation of amount and kind of grignard reagent; other solvents; various reaction times and temp.; Product distribution;
参考文献
Mathre, David J.; Jones, Todd K.; Xavier, Lyndon C.; Blacklock, Thomas J.; Reamer, Robert A.; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 751 - 762
反应条件
1: With (R)-2,2'-dihydroxy-1,1'-binaphthyl; boric acid in acetonitrile Heating; 2: With hydrogenchloride in diethyl ether; water Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 11 p. 3828 - 3833
反应条件
1.1: Mg; iodine / tetrahydrofuran / Heating 1.2: 45 percent / tetrahydrofuran / Heating 2.1: 15 percent / KOH / methanol / 4 h / Heating View Scheme
参考文献
European Journal of Organic Chemistry, , # 6 p. 1082 - 1096
反应条件
1: bromobenzene With magnesium in tetrahydrofuran 2: (S)-Tetrahydro-1H,3H-pyrrolo[1,2-c]oxazole-1,3-dione in tetrahydrofuran Further stages.;
参考文献
Kell, Roger J.; Hodge, Philip; Snedden, Peter; Watson, David
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 18 p. 3238 - 3243
反应条件
1: 95 percent / SOCl2 / 8 h / 25 °C 2: 1) Mg / 1) THF, 30 min, r.t., 2) THF, 0 deg C, 3 h 3: 92 percent / KOH / methanol / 4 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 49, # 23 p. 5127 - 5132
反应条件
1: Et3N / tetrahydrofuran / 0.5 h / 0 °C 2: tetrahydrofuran / 4 h / -15 - 0 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 28, # 4 p. 487 - 490
反应条件
1: in tetrahydrofuran T=0°C; Grignard reaction; 3.5 h; Inert atmosphere; 2: With potassium hydroxide in methanol 24 h; Reflux;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 95 - 99