(R)-(+)-α,α-二苯基脯氨醇合成路线 (共 61 条)
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 17 h;
参考文献
Hayashi, Yujiro; Gotoh, Hiroaki; Hayashi, Takaaki; Shoji, Mitsuru
Angewandte Chemie - International Edition, 2005 , vol. 44, # 27 p. 4212 - 4215
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Roussel, Solveig; Billard, Thierry; Langlois, Bernard R.; Saint-James, Laurent
Chemistry - A European Journal, 2005 , vol. 11, # 3 p. 939 - 944
反应条件
diethylamino-sulfur trifluoride in dichloromethane T=0 - 20°C; 6.5 h; Inert atmosphere;
参考文献
Sparr, Christof; Tanzer, Eva-Maria; Bachmann, Julia; Gilmour, Ryan
Synthesis, 2010 , # 8 art. no. T20109SS, p. 1394 - 1397
反应条件
PhTMG; phosphorochloridic acid diphenyl ester in dichloromethane T=-40 - 20°C;
参考文献
Paz, Jairo; Perez-Balado, Carlos; Iglesias, Beatriz; Munoz, Luis
Journal of Organic Chemistry, 2010 , vol. 75, # 9 p. 3037 - 3046
反应条件
sodium hydroxide in dichloromethane T=20°C; 2 h;
参考文献
Palomo, Claudio; Vera, Silvia; Mielgo, Antonia; Gomez-Bengoa, Enrique
Angewandte Chemie - International Edition, 2006 , vol. 45, # 36 p. 5984 - 5987
反应条件
in formic acid 4 h; Heating;
参考文献
Dreisbach, Claus; Wischnewski, Gisela; Kragl, Ugo; Wandrey, Christian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 7 p. 875 - 878
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 45, # 2 p. 145 - 155
反应条件
4 A molecular sieve in toluene T=20°C; 1 h;
参考文献
Organic Letters, , vol. 9, # 19 p. 3769 - 3771
反应条件
in toluene T=20°C; 1 h; Product distribution / selectivity;
参考文献
US2008/139851 A1, ;
Page/Page column 7 ;
反应条件
in toluene T=20°C; 0.6 h;
参考文献
Evans, David A.; Kvaerno, Lisbet; Dunn, Travis B.; Beauchemin, Andre; Raymer, Brian; Mulder, Jason A.; Olhava, Edward J.; Juhl, Martin; Kagechika, Katsuji; Favor, David A.
Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16295 - 16309