(R)-(+)-α,α-二苯基脯氨醇合成路线 (共 61 条)
反应条件
in toluene byproducts: H2O; refluxing of pyrrolidine deriv. and methylboronic acid in toluene for 3 h; evapn. of solvent in vac.;
参考文献
Corey, E. J.; Bakshi, Raman K.; Shibata, Saizo; Chen Chung-Pin; Singh, Vinod K.
Journal of the American Chemical Society, 1987 , vol. 109, # 25 p. 7925 - 7926
反应条件
in toluene 3 h; Heating;
参考文献
Jockel, Holger; Schmidt, Reinhard; Jope, Helge; Schmalz, Hans-Guenther
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 1 p. 69 - 76
反应条件
in tetrahydrofuran; toluene reflux for 30 min; solvents are removed;
参考文献
Chavant, P. Y.; Vaultier, M.
Journal of Organometallic Chemistry, 1993 , vol. 455, # 1-2 p. 37 - 46
反应条件
diethylamino-sulfur trifluoride in dichloromethane T=0 - 20°C; 6.5 h; Inert atmosphere;
参考文献
Sparr, Christof; Tanzer, Eva-Maria; Bachmann, Julia; Gilmour, Ryan
Synthesis, 2010 , # 8 art. no. T20109SS, p. 1394 - 1397
反应条件
hydrogenchloride in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Huskey, Su-er Wu; Chiu, Shuet-Hing Lee
Patent: US2004/23960 A1, 2004 ;
US 20040023960 A1
反应条件
1: N,N-diethylaniline hydrochloride With sodium tetrahydroborate in ethylene glycol dimethyl ether; dichloromethane; water T=20 - 30°C; 6 h; Inert atmosphereLarge scale reaction; 2: (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol in ethylene glycol dimethyl ether; dichloromethane T=25 - 30°C; 1 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 16, # 4 p. 710 - 713
参考文献
Fuji, Kaoru; Kawabata, Takeo; Ohmori, Toshiumi; Shang, Muhong; Node, Manabu
Heterocycles, 1998 , vol. 47, # 2 p. 951 - 964
反应条件
potassium carbonate in ethanol Heating;
参考文献
Watanabe, Masami; Soai, Kenso
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 7 p. 837 - 842
反应条件
in toluene
3 h; Heating;
参考文献
Hong, Sungwoo; Corey
Journal of the American Chemical Society, 2006 , vol. 128, # 4 p. 1346 - 1352
反应条件
N-ethyl-N,N-diisopropylamine in benzene
T=20 - 40°C; 1.5 h; Inert atmosphere;
参考文献
Mukherjee, Santanu; Corey
Organic Letters, 2010 , vol. 12, # 3 p. 632 - 635