3-甲基氨基-1,2,3,4-四氢咔唑合成路线 （共 4 条）
反应条件
sulfuric acid in water T=95 - 100°C;
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
反应条件
sodium hydrogencarbonate; methylamine in 2-ethoxy-ethanol
参考文献
Sterling Drug Inc.
Patent: US4062864 A1, 1977 ;
反应条件
1: With magnesium sulfate; acetic acid in tetrahydrofuran; methanol T=20°C; 0.25 h; 2: With sodium cyanoborohydride in tetrahydrofuran; methanol T=20°C; 12 h;
参考文献
Ulven, Trond; Kostenis, Evi
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 897 - 900
反应条件
1.1: methanol-d1 / 2 h / 20 °C 1.2: 18 h / 25 - 30 °C / pH Ca. 6 2.1: sulfuric acid / water / 95 - 100 °C View Scheme
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
