3-溴-4-甲基-5-硝基苯甲酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid RefluxMolecular sieve;
参考文献
Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M.
Tetrahedron, 2014 , vol. 70, # 2 p. 318 - 326
反应条件
1: DBDMH / sulfuric acid / 16 h / 20 °C 2: thionyl chloride / -5 °C / Reflux View Scheme
参考文献
Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M.
Tetrahedron, 2014 , vol. 70, # 2 p. 318 - 326
反应条件
1: With tin(ll) chloride in ethanol 0.5 h; Reflux; 2: With sodium hydroxide in dichloromethane; water
参考文献
Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M.
Tetrahedron, 2014 , vol. 70, # 2 p. 318 - 326
反应条件
1: With iron; acetic acid in tetrahydrofuran 10 h; Reflux; 2: With acetic acid; sodium nitrite 10 h; Reflux;
参考文献
ZHEJIANG BETA PHARMA INC.; KANG, Xinshan; FINE, Richard M.; KLEBANSKY, Borris; LONG, Wei; MA, Cunbo; LI, Haijun; WANG, Yanping; HU, Yunyan; WANG, Yinxiang
Patent: WO2011/38579 A1, 2011 ;
Location in patent: Page/Page column 36 ;
WO 2011/038579 A1
反应条件
1.1: acetic acid; iron / tetrahydrofuran / 10 h / Reflux 1.2: 10 h / Reflux 2.1: water; lithium hydroxide hydrate / ethanol / 20 h / 20 °C 2.2: pH 4 View Scheme
参考文献
Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M.
Tetrahedron, 2014 , vol. 70, # 2 p. 318 - 326
反应条件
1.1: tin(ll) chloride / ethanol / 0.5 h / |Reflux 2.1: acetic acid; sodium nitrite / water 3.1: sodium hydroxide; water / ethanol / 4 h / 20 °C 4.1: thionyl chloride / 1 h / |Reflux 4.2: 0 °C 5.1: potassium hydroxide; [bis(acetoxy)iodo]benzene / 3 h / 0 °C 6.1: water; potassium hydroxide / methanol / 48 h / |Reflux View Scheme
参考文献
Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M.
Tetrahedron, 2014 , vol. 70, # 2 p. 318 - 326
反应条件
1: tin(ll) chloride / ethanol / 0.5 h / |Reflux 2: acetic acid; sodium nitrite / water 3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
