3-氯-2-羟基-5-硝基吡啶合成路线 （共 12 条）
反应条件
1: With hydrogenchloride T=20°C; 2: With sodium chlorate T=50°C; 1 h;
参考文献
Bajare, Swapnil; Anthony, Jessy; Nair, Amrutha; Marita, Rosalind; Damre, Anagha; Patel, Dharmeshkumar; Rao, Chandrika; Sivaramakrishnan; Deka, Nabajyoti
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 355 - 360
反应条件
hydrogenchloride; water
反应条件
sulfuric acid; water; sodium nitrite
参考文献
Journal of the Chemical Society, , p. 2590,2593
反应条件
1: aqueous HCl; chlorine 2: water; sulfuric acid; sodium nitrite View Scheme
参考文献
Journal of the Chemical Society, , p. 2590,2593
反应条件
quinoline; phosphorus oxytribromide T=120°C; 2 h;
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
反应条件
quinoline; trichlorophosphate T=120°C; 2 h;
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
反应条件
trichlorophosphate in quinoline
参考文献
Abbott Laboratories
Patent: US6133253 A1, 2000 ;
参考文献
BASF Aktiengesellschaft
Patent: US6432880 B1, 2002 ;
反应条件
1: 90 percent / POBr3, quinoline / 2 h / 120 °C 2: 81 percent / Fe, AcOH / H2O / 2 h / below 50 deg C View Scheme
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
反应条件
1: 98 percent / POCl3, quinoline / 2 h / 120 °C 2: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C View Scheme
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
