1: (+)-(R)-5-bromo-1-methyl-2-(triphenylmethyl)isoindoline With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-65°C; 1 h; 2: bis-(2-hydroxy-ethyl)-amine in ethanol T=45°C; 1 h;

in tetrahydrofuran; hexane 0.333333 h;

1.1: AcOH / 1,2-dimethoxy-ethane; H2O / 0.5 h / 20 °C 1.2: 92 percent / [(C6H5)3P]2PdCl2; Na2CO3 / 1.5 h / Heating 2.1: 86 percent / HCl / ethanol; H2O / 1 h / 20 °C View Scheme